| http://purl.uniprot.org/citations/28805659 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28805659 | http://www.w3.org/2000/01/rdf-schema#comment | "Atypical antipsychotics such as olanzapine often induce excessive weight gain and type 2 diabetes. However, the mechanisms underlying these drug-induced metabolic perturbations remain poorly understood. Here, we used an experimental model that reproduces olanzapine-induced hyperphagia and obesity in female C57BL/6 mice. We found that olanzapine treatment acutely increased food intake, impaired glucose tolerance, and altered physical activity and energy expenditure in mice. Furthermore, olanzapine-induced hyperphagia and weight gain were blunted in mice lacking the serotonin 2C receptor (HTR2C). Finally, we showed that treatment with the HTR2C-specific agonist lorcaserin suppressed olanzapine-induced hyperphagia and weight gain. Lorcaserin treatment also improved glucose tolerance in olanzapine-fed mice. Collectively, our studies suggest that olanzapine exerts some of its untoward metabolic effects via antagonism of HTR2C."xsd:string |
| http://purl.uniprot.org/citations/28805659 | http://purl.org/dc/terms/identifier | "doi:10.1172/jci93362"xsd:string |
| http://purl.uniprot.org/citations/28805659 | http://purl.uniprot.org/core/author | "Liu C."xsd:string |
| http://purl.uniprot.org/citations/28805659 | http://purl.uniprot.org/core/author | "Lee S."xsd:string |
| http://purl.uniprot.org/citations/28805659 | http://purl.uniprot.org/core/author | "Ahmed N."xsd:string |
| http://purl.uniprot.org/citations/28805659 | http://purl.uniprot.org/core/author | "Elmquist J.K."xsd:string |
| http://purl.uniprot.org/citations/28805659 | http://purl.uniprot.org/core/author | "Lord C.C."xsd:string |
| http://purl.uniprot.org/citations/28805659 | http://purl.uniprot.org/core/author | "Wan R."xsd:string |
| http://purl.uniprot.org/citations/28805659 | http://purl.uniprot.org/core/author | "Castorena C.M."xsd:string |
| http://purl.uniprot.org/citations/28805659 | http://purl.uniprot.org/core/author | "Mathew D."xsd:string |
| http://purl.uniprot.org/citations/28805659 | http://purl.uniprot.org/core/author | "Wyler S.C."xsd:string |
| http://purl.uniprot.org/citations/28805659 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28805659 | http://purl.uniprot.org/core/name | "J Clin Invest"xsd:string |
| http://purl.uniprot.org/citations/28805659 | http://purl.uniprot.org/core/pages | "3402-3406"xsd:string |
| http://purl.uniprot.org/citations/28805659 | http://purl.uniprot.org/core/title | "The atypical antipsychotic olanzapine causes weight gain by targeting serotonin receptor 2C."xsd:string |
| http://purl.uniprot.org/citations/28805659 | http://purl.uniprot.org/core/volume | "127"xsd:string |
| http://purl.uniprot.org/citations/28805659 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28805659 |
| http://purl.uniprot.org/citations/28805659 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28805659 |
| http://purl.uniprot.org/uniprot/#_B1ATN4-mappedCitation-28805659 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28805659 |
| http://purl.uniprot.org/uniprot/#_B2RUD4-mappedCitation-28805659 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28805659 |
| http://purl.uniprot.org/uniprot/#_Q8BZI5-mappedCitation-28805659 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28805659 |
| http://purl.uniprot.org/uniprot/#_P34968-mappedCitation-28805659 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28805659 |
| http://purl.uniprot.org/uniprot/#_Q8BUB1-mappedCitation-28805659 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28805659 |
| http://purl.uniprot.org/uniprot/#_S4R2T0-mappedCitation-28805659 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28805659 |