| http://purl.uniprot.org/citations/28807942 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28807942 | http://www.w3.org/2000/01/rdf-schema#comment | "Nuclear focal adhesion kinase (FAK) is a potentially important regulator of gene expression in cancer, impacting both cellular function and the composition of the surrounding tumor microenvironment. Here, we report in a murine model of skin squamous cell carcinoma (SCC) that nuclear FAK regulates Runx1-dependent transcription of insulin-like growth factor binding protein 3 (IGFBP3), and that this regulates SCC cell-cycle progression and tumor growth in vivo Furthermore, we identified a novel molecular complex between FAK and Runx1 in the nucleus of SCC cells and showed that FAK interacted with a number of Runx1-regulatory proteins, including Sin3a and other epigenetic modifiers known to alter Runx1 transcriptional function through posttranslational modification. These findings provide important new insights into the role of FAK as a scaffolding protein in molecular complexes that regulate gene transcription. Cancer Res; 77(19); 5301-12. ©2017 AACR."xsd:string |
| http://purl.uniprot.org/citations/28807942 | http://purl.org/dc/terms/identifier | "doi:10.1158/0008-5472.can-17-0418"xsd:string |
| http://purl.uniprot.org/citations/28807942 | http://purl.uniprot.org/core/author | "Frame M.C."xsd:string |
| http://purl.uniprot.org/citations/28807942 | http://purl.uniprot.org/core/author | "Brunton V.G."xsd:string |
| http://purl.uniprot.org/citations/28807942 | http://purl.uniprot.org/core/author | "Patel H."xsd:string |
| http://purl.uniprot.org/citations/28807942 | http://purl.uniprot.org/core/author | "Byron A."xsd:string |
| http://purl.uniprot.org/citations/28807942 | http://purl.uniprot.org/core/author | "Serrels B."xsd:string |
| http://purl.uniprot.org/citations/28807942 | http://purl.uniprot.org/core/author | "Sims A.H."xsd:string |
| http://purl.uniprot.org/citations/28807942 | http://purl.uniprot.org/core/author | "Cartier J."xsd:string |
| http://purl.uniprot.org/citations/28807942 | http://purl.uniprot.org/core/author | "Serrels A."xsd:string |
| http://purl.uniprot.org/citations/28807942 | http://purl.uniprot.org/core/author | "Canel M."xsd:string |
| http://purl.uniprot.org/citations/28807942 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28807942 | http://purl.uniprot.org/core/name | "Cancer Res"xsd:string |
| http://purl.uniprot.org/citations/28807942 | http://purl.uniprot.org/core/pages | "5301-5312"xsd:string |
| http://purl.uniprot.org/citations/28807942 | http://purl.uniprot.org/core/title | "Nuclear FAK and Runx1 Cooperate to Regulate IGFBP3, Cell-Cycle Progression, and Tumor Growth."xsd:string |
| http://purl.uniprot.org/citations/28807942 | http://purl.uniprot.org/core/volume | "77"xsd:string |
| http://purl.uniprot.org/citations/28807942 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28807942 |
| http://purl.uniprot.org/citations/28807942 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28807942 |
| http://purl.uniprot.org/uniprot/#_G3UWD2-mappedCitation-28807942 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28807942 |
| http://purl.uniprot.org/uniprot/#_G3X9W7-mappedCitation-28807942 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28807942 |
| http://purl.uniprot.org/uniprot/#_P34152-mappedCitation-28807942 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28807942 |
| http://purl.uniprot.org/uniprot/#_Q2VQT9-mappedCitation-28807942 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28807942 |
| http://purl.uniprot.org/uniprot/#_Q8BP94-mappedCitation-28807942 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28807942 |
| http://purl.uniprot.org/uniprot/#_K7Q751-mappedCitation-28807942 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28807942 |