http://purl.uniprot.org/citations/28808929 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/28808929 | http://www.w3.org/2000/01/rdf-schema#comment | "PurposeHO-1 has been proved to be associated with tumor aggressivity and poor prognosis in various cancers. Our study provides the first study to demonstrate the relationship of HO-1 expression and clinical characteristics in ovarian cancer patients.MethodsImmunohistochemistry and western blotting were used to examine the expression of HO-1 in tissue species and fresh tissues. CCK-8 was used to investigate cell viability. Transwell chamber was performed to estimate migration and invasion capacities in A2780 and Skov-3 cells.ResultsImmunohistochemistry and western blotting showed that the expression of HO-1 was higher in ovarian cancer tissues than normal ovarian tissues. High expression of HO-1 was significantly associated with serous ovarian cancer, high FIGO stage, lymph node metastasis, and non-optimal debulking. Patients with high expression of HO-1 exhibited an unfavorable prognosis. In vitro inducing the expression of HO-1 promoted the proliferation and metastasis of A2780 and Skov-3 cells, with the increased expressions of mesenchymal marker (Vimentin), epithelial-mesenchymal transition-associated transcript factor (Zeb-1), anti-apoptotic protein (Bcl-2), and the decreased expressions of epithelial marker (Keratin) and pro-apoptotic protein (Bax). Meanwhile, after incubating A2780 and Skov-3 together with HO-1 inhibitor, above results could be reversed.ConclusionHO-1 might be a potential marker for prediction of ovarian cancer prognosis and a target for ovarian cancer treatment."xsd:string |
http://purl.uniprot.org/citations/28808929 | http://purl.org/dc/terms/identifier | "doi:10.1007/s12094-017-1738-7"xsd:string |
http://purl.uniprot.org/citations/28808929 | http://purl.uniprot.org/core/author | "Lu J."xsd:string |
http://purl.uniprot.org/citations/28808929 | http://purl.uniprot.org/core/author | "Liu P."xsd:string |
http://purl.uniprot.org/citations/28808929 | http://purl.uniprot.org/core/author | "Xu Y."xsd:string |
http://purl.uniprot.org/citations/28808929 | http://purl.uniprot.org/core/author | "Zhao Z."xsd:string |
http://purl.uniprot.org/citations/28808929 | http://purl.uniprot.org/core/author | "Xue J."xsd:string |
http://purl.uniprot.org/citations/28808929 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
http://purl.uniprot.org/citations/28808929 | http://purl.uniprot.org/core/name | "Clin Transl Oncol"xsd:string |
http://purl.uniprot.org/citations/28808929 | http://purl.uniprot.org/core/pages | "491-499"xsd:string |
http://purl.uniprot.org/citations/28808929 | http://purl.uniprot.org/core/title | "High expression of HO-1 predicts poor prognosis of ovarian cancer patients and promotes proliferation and aggressiveness of ovarian cancer cells."xsd:string |
http://purl.uniprot.org/citations/28808929 | http://purl.uniprot.org/core/volume | "20"xsd:string |
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