| http://purl.uniprot.org/citations/28813657 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28813657 | http://www.w3.org/2000/01/rdf-schema#comment | "Mechanisms by which interferon (IFN)-γ activates genes to promote macrophage activation are well studied, but little is known about mechanisms and functions of IFN-γ-mediated gene repression. We used an integrated transcriptomic and epigenomic approach to analyze chromatin accessibility, histone modifications, transcription-factor binding, and gene expression in IFN-γ-primed human macrophages. IFN-γ suppressed basal expression of genes corresponding to an "M2"-like homeostatic and reparative phenotype. IFN-γ repressed genes by suppressing the function of enhancers enriched for binding by transcription factor MAF. Mechanistically, IFN-γ disassembled a subset of enhancers by inducing coordinate suppression of binding by MAF, lineage-determining transcription factors, and chromatin accessibility. Genes associated with MAF-binding enhancers were suppressed in macrophages isolated from rheumatoid-arthritis patients, revealing a disease-associated signature of IFN-γ-mediated repression. These results identify enhancer inactivation and disassembly as a mechanism of IFN-γ-mediated gene repression and reveal that MAF regulates the macrophage enhancer landscape and is suppressed by IFN-γ to augment macrophage activation."xsd:string |
| http://purl.uniprot.org/citations/28813657 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2017.07.017"xsd:string |
| http://purl.uniprot.org/citations/28813657 | http://purl.uniprot.org/core/author | "Chen J."xsd:string |
| http://purl.uniprot.org/citations/28813657 | http://purl.uniprot.org/core/author | "Li J."xsd:string |
| http://purl.uniprot.org/citations/28813657 | http://purl.uniprot.org/core/author | "Park S.H."xsd:string |
| http://purl.uniprot.org/citations/28813657 | http://purl.uniprot.org/core/author | "Qiao Y."xsd:string |
| http://purl.uniprot.org/citations/28813657 | http://purl.uniprot.org/core/author | "Kang K."xsd:string |
| http://purl.uniprot.org/citations/28813657 | http://purl.uniprot.org/core/author | "Berg K."xsd:string |
| http://purl.uniprot.org/citations/28813657 | http://purl.uniprot.org/core/author | "Ivashkiv L.B."xsd:string |
| http://purl.uniprot.org/citations/28813657 | http://purl.uniprot.org/core/author | "Kang K.'"xsd:string |
| http://purl.uniprot.org/citations/28813657 | http://purl.uniprot.org/core/author | "Park-Min K.H."xsd:string |
| http://purl.uniprot.org/citations/28813657 | http://purl.uniprot.org/core/author | "Nabozny G."xsd:string |
| http://purl.uniprot.org/citations/28813657 | http://purl.uniprot.org/core/author | "Hanidu A."xsd:string |
| http://purl.uniprot.org/citations/28813657 | http://purl.uniprot.org/core/author | "Giannopoulou E."xsd:string |
| http://purl.uniprot.org/citations/28813657 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28813657 | http://purl.uniprot.org/core/name | "Immunity"xsd:string |
| http://purl.uniprot.org/citations/28813657 | http://purl.uniprot.org/core/pages | "235-250.e4"xsd:string |
| http://purl.uniprot.org/citations/28813657 | http://purl.uniprot.org/core/title | "Interferon-gamma Represses M2 Gene Expression in Human Macrophages by Disassembling Enhancers Bound by the Transcription Factor MAF."xsd:string |
| http://purl.uniprot.org/citations/28813657 | http://purl.uniprot.org/core/volume | "47"xsd:string |
| http://purl.uniprot.org/citations/28813657 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28813657 |
| http://purl.uniprot.org/citations/28813657 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28813657 |
| http://purl.uniprot.org/uniprot/#_A0A7R8GUN6-mappedCitation-28813657 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28813657 |
| http://purl.uniprot.org/uniprot/#_A8YQE4-mappedCitation-28813657 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28813657 |
| http://purl.uniprot.org/uniprot/#_A1Z2M2-mappedCitation-28813657 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28813657 |