| http://purl.uniprot.org/citations/28814508 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28814508 | http://www.w3.org/2000/01/rdf-schema#comment | "TorsinA is an essential AAA+ ATPase requiring LAP1 or LULL1 as cofactors. The dynamics of the Torsin/cofactor system remain poorly understood, with previous models invoking Torsin/cofactor assemblies with fixed stoichiometries. Here we demonstrate that TorsinA assembles into homotypic oligomers in the presence of ATP. Torsin variants mutated at the "back" interface disrupt homo-oligomerization but still show robust ATPase activity in the presence of its cofactors. These Torsin mutants are severely compromised in their ability to rescue nuclear envelope defects in Torsin-deficient cells, suggesting that TorsinA homo-oligomers play a key role in vivo. Engagement of the oligomer by LAP1 triggers ATP hydrolysis and rapid complex disassembly. Thus the Torsin complex is a highly dynamic assembly whose oligomeric state is tightly controlled by distinctively localized cellular cofactors. Our discovery that LAP1 serves as a modulator of the oligomeric state of an AAA+ protein establishes a novel means of regulating this important class of oligomeric ATPases."xsd:string |
| http://purl.uniprot.org/citations/28814508 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e17-05-0281"xsd:string |
| http://purl.uniprot.org/citations/28814508 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/28814508 | http://purl.uniprot.org/core/author | "Schlieker C."xsd:string |
| http://purl.uniprot.org/citations/28814508 | http://purl.uniprot.org/core/author | "Yokoyama T."xsd:string |
| http://purl.uniprot.org/citations/28814508 | http://purl.uniprot.org/core/author | "Shigematsu H."xsd:string |
| http://purl.uniprot.org/citations/28814508 | http://purl.uniprot.org/core/author | "Chase A.R."xsd:string |
| http://purl.uniprot.org/citations/28814508 | http://purl.uniprot.org/core/author | "Laudermilch E."xsd:string |
| http://purl.uniprot.org/citations/28814508 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28814508 | http://purl.uniprot.org/core/name | "Mol Biol Cell"xsd:string |
| http://purl.uniprot.org/citations/28814508 | http://purl.uniprot.org/core/pages | "2765-2772"xsd:string |
| http://purl.uniprot.org/citations/28814508 | http://purl.uniprot.org/core/title | "Dynamic functional assembly of the Torsin AAA+ ATPase and its modulation by LAP1."xsd:string |
| http://purl.uniprot.org/citations/28814508 | http://purl.uniprot.org/core/volume | "28"xsd:string |
| http://purl.uniprot.org/citations/28814508 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28814508 |
| http://purl.uniprot.org/citations/28814508 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28814508 |
| http://purl.uniprot.org/uniprot/#_P11142-mappedCitation-28814508 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28814508 |
| http://purl.uniprot.org/uniprot/#_B3KTV0-mappedCitation-28814508 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28814508 |
| http://purl.uniprot.org/uniprot/#_B4DTX2-mappedCitation-28814508 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28814508 |
| http://purl.uniprot.org/uniprot/#_B4E1Q1-mappedCitation-28814508 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28814508 |
| http://purl.uniprot.org/uniprot/#_A8K7Q2-mappedCitation-28814508 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28814508 |
| http://purl.uniprot.org/uniprot/#_Q53GZ6-mappedCitation-28814508 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28814508 |
| http://purl.uniprot.org/uniprot/#_Q53HF2-mappedCitation-28814508 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28814508 |
| http://purl.uniprot.org/uniprot/#_Q96IS6-mappedCitation-28814508 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28814508 |
| http://purl.uniprot.org/uniprot/#_Q96BE0-mappedCitation-28814508 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28814508 |