| http://purl.uniprot.org/citations/28821818 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28821818 | http://www.w3.org/2000/01/rdf-schema#comment | "Activated macrophages have a greater ability of phagocytosis against pathogens that is mediated by large-scale actin rearrangement. However, molecular machineries that conduct this task have not been fully identified. Here, we demonstrate an unanticipated role of TAGLN2, a 22-kDa actin-binding protein, in Toll-like receptor (TLR)-stimulated phagocytosis. TAGLN2 was greatly induced in macrophages in response to lipopolysaccharide (LPS), a ligand for TLR4, partly via the NF-κB pathway. TAGLN2-deficient macrophages (TAGLN2 -/-) showed defective phagocytic functions of IgM- and IgG-coated sheep red blood cells as well as bacteria. Cell signaling pathways involved in actin rearrangement-PI3 kinase/AKT and Ras-ERK-were also down-regulated in LPS-stimulated TAGLN2-deficient macrophages. Moreover, TAGLN2 -/- mice showed higher mortality after bacterial infection than wild-type littermates. Thus, our results revealed a novel function of TAGLN2 as a molecular armament required for host defense."xsd:string |
| http://purl.uniprot.org/citations/28821818 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41598-017-09144-x"xsd:string |
| http://purl.uniprot.org/citations/28821818 | http://purl.uniprot.org/core/author | "Kim S.M."xsd:string |
| http://purl.uniprot.org/citations/28821818 | http://purl.uniprot.org/core/author | "Kim C.H."xsd:string |
| http://purl.uniprot.org/citations/28821818 | http://purl.uniprot.org/core/author | "Lee K.S."xsd:string |
| http://purl.uniprot.org/citations/28821818 | http://purl.uniprot.org/core/author | "Kim H.R."xsd:string |
| http://purl.uniprot.org/citations/28821818 | http://purl.uniprot.org/core/author | "Lee H.S."xsd:string |
| http://purl.uniprot.org/citations/28821818 | http://purl.uniprot.org/core/author | "Lee S.M."xsd:string |
| http://purl.uniprot.org/citations/28821818 | http://purl.uniprot.org/core/author | "Yoon M.H."xsd:string |
| http://purl.uniprot.org/citations/28821818 | http://purl.uniprot.org/core/author | "Jung I.D."xsd:string |
| http://purl.uniprot.org/citations/28821818 | http://purl.uniprot.org/core/author | "Park Y.M."xsd:string |
| http://purl.uniprot.org/citations/28821818 | http://purl.uniprot.org/core/author | "Kwon M.S."xsd:string |
| http://purl.uniprot.org/citations/28821818 | http://purl.uniprot.org/core/author | "Jun C.D."xsd:string |
| http://purl.uniprot.org/citations/28821818 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28821818 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/28821818 | http://purl.uniprot.org/core/pages | "8731"xsd:string |
| http://purl.uniprot.org/citations/28821818 | http://purl.uniprot.org/core/title | "An Essential Role for TAGLN2 in Phagocytosis of Lipopolysaccharide-activated Macrophages."xsd:string |
| http://purl.uniprot.org/citations/28821818 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/28821818 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28821818 |
| http://purl.uniprot.org/citations/28821818 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28821818 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YXG6-mappedCitation-28821818 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28821818 |
| http://purl.uniprot.org/uniprot/#_Q9WVA4-mappedCitation-28821818 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28821818 |
| http://purl.uniprot.org/uniprot/A0A0A6YXG6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28821818 |
| http://purl.uniprot.org/uniprot/Q9WVA4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28821818 |