| http://purl.uniprot.org/citations/28825699 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28825699 | http://www.w3.org/2000/01/rdf-schema#comment | "Polarized epithelia develop distinct cell surface domains, with the apical membrane acquiring characteristic morphological features such as microvilli. Cell polarization is driven by polarity determinants including the evolutionarily conserved partitioning-defective (PAR) proteins that are separated into distinct cortical domains. PAR protein segregation is thought to be a consequence of asymmetric actomyosin contractions. The mechanism of activation of apically polarized actomyosin contractility is unknown. Here we show that the Cdc42 effector MRCK activates myosin-II at the apical pole to segregate aPKC-Par6 from junctional Par3, defining the apical domain. Apically polarized MRCK-activated actomyosin contractility is reinforced by cooperation with aPKC-Par6 downregulating antagonistic RhoA-driven junctional actomyosin contractility, and drives polarization of cytosolic brush border determinants and apical morphogenesis. MRCK-activated polarized actomyosin contractility is required for apical differentiation and morphogenesis in vertebrate epithelia and Drosophila photoreceptors. Our results identify an apical origin of actomyosin-driven morphogenesis that couples cytoskeletal reorganization to PAR polarity signalling."xsd:string |
| http://purl.uniprot.org/citations/28825699 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncb3592"xsd:string |
| http://purl.uniprot.org/citations/28825699 | http://purl.uniprot.org/core/author | "Balda M.S."xsd:string |
| http://purl.uniprot.org/citations/28825699 | http://purl.uniprot.org/core/author | "Matter K."xsd:string |
| http://purl.uniprot.org/citations/28825699 | http://purl.uniprot.org/core/author | "Olson M."xsd:string |
| http://purl.uniprot.org/citations/28825699 | http://purl.uniprot.org/core/author | "Zihni C."xsd:string |
| http://purl.uniprot.org/citations/28825699 | http://purl.uniprot.org/core/author | "Carlton J."xsd:string |
| http://purl.uniprot.org/citations/28825699 | http://purl.uniprot.org/core/author | "Pichaud F."xsd:string |
| http://purl.uniprot.org/citations/28825699 | http://purl.uniprot.org/core/author | "Leung T.K.C."xsd:string |
| http://purl.uniprot.org/citations/28825699 | http://purl.uniprot.org/core/author | "Terry S."xsd:string |
| http://purl.uniprot.org/citations/28825699 | http://purl.uniprot.org/core/author | "Vlassaks E."xsd:string |
| http://purl.uniprot.org/citations/28825699 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28825699 | http://purl.uniprot.org/core/name | "Nat Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/28825699 | http://purl.uniprot.org/core/pages | "1049-1060"xsd:string |
| http://purl.uniprot.org/citations/28825699 | http://purl.uniprot.org/core/title | "An apical MRCK-driven morphogenetic pathway controls epithelial polarity."xsd:string |
| http://purl.uniprot.org/citations/28825699 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/28825699 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28825699 |
| http://purl.uniprot.org/citations/28825699 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28825699 |
| http://purl.uniprot.org/uniprot/#_Q07960-mappedCitation-28825699 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28825699 |
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| http://purl.uniprot.org/uniprot/#_Q14160-mappedCitation-28825699 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28825699 |
| http://purl.uniprot.org/uniprot/#_Q14161-mappedCitation-28825699 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28825699 |
| http://purl.uniprot.org/uniprot/#_A4D1P6-mappedCitation-28825699 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28825699 |
| http://purl.uniprot.org/uniprot/#_F6J1D0-mappedCitation-28825699 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28825699 |