| http://purl.uniprot.org/citations/28826478 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28826478 | http://www.w3.org/2000/01/rdf-schema#comment | "Postnatal development of skeletal muscle is a highly dynamic period of tissue remodeling. Here, we used RNA-seq to identify transcriptome changes from late embryonic to adult mouse muscle and demonstrate that alternative splicing developmental transitions impact muscle physiology. The first 2 weeks after birth are particularly dynamic for differential gene expression and alternative splicing transitions, and calcium-handling functions are significantly enriched among genes that undergo alternative splicing. We focused on the postnatal splicing transitions of the three calcineurin A genes, calcium-dependent phosphatases that regulate multiple aspects of muscle biology. Redirected splicing of calcineurin A to the fetal isoforms in adult muscle and in differentiated C2C12 slows the timing of muscle relaxation, promotes nuclear localization of calcineurin target Nfatc3, and/or affects expression of Nfatc transcription targets. The results demonstrate a previously unknown specificity of calcineurin isoforms as well as the broader impact of alternative splicing during muscle postnatal development."xsd:string |
| http://purl.uniprot.org/citations/28826478 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.27192"xsd:string |
| http://purl.uniprot.org/citations/28826478 | http://purl.uniprot.org/core/author | "Li W."xsd:string |
| http://purl.uniprot.org/citations/28826478 | http://purl.uniprot.org/core/author | "Xia Z."xsd:string |
| http://purl.uniprot.org/citations/28826478 | http://purl.uniprot.org/core/author | "Cooper T.A."xsd:string |
| http://purl.uniprot.org/citations/28826478 | http://purl.uniprot.org/core/author | "Rodney G.G."xsd:string |
| http://purl.uniprot.org/citations/28826478 | http://purl.uniprot.org/core/author | "Loehr J.A."xsd:string |
| http://purl.uniprot.org/citations/28826478 | http://purl.uniprot.org/core/author | "Brinegar A.E."xsd:string |
| http://purl.uniprot.org/citations/28826478 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28826478 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/28826478 | http://purl.uniprot.org/core/pages | "e27192"xsd:string |
| http://purl.uniprot.org/citations/28826478 | http://purl.uniprot.org/core/title | "Extensive alternative splicing transitions during postnatal skeletal muscle development are required for calcium handling functions."xsd:string |
| http://purl.uniprot.org/citations/28826478 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/28826478 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28826478 |
| http://purl.uniprot.org/citations/28826478 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28826478 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YVV8-mappedCitation-28826478 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28826478 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YWB0-mappedCitation-28826478 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28826478 |
| http://purl.uniprot.org/uniprot/#_A0A087WQ31-mappedCitation-28826478 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28826478 |
| http://purl.uniprot.org/uniprot/#_A0A087WQ95-mappedCitation-28826478 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28826478 |
| http://purl.uniprot.org/uniprot/#_A0A087WQF1-mappedCitation-28826478 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28826478 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YWG1-mappedCitation-28826478 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28826478 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YWJ5-mappedCitation-28826478 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28826478 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YWK1-mappedCitation-28826478 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28826478 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YX59-mappedCitation-28826478 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28826478 |