| http://purl.uniprot.org/citations/28827400 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28827400 | http://www.w3.org/2000/01/rdf-schema#comment | "While microRNAs (miRNAs) regulate the vast majority of protein-encoding transcripts, little is known about how miRNAs themselves are degraded. We recently described Tudor-staphylococcal/micrococcal-like nuclease (TSN)-mediated miRNA decay (TumiD) as a cellular pathway in which the nuclease TSN promotes the decay of miRNAs that contain CA and/or UA dinucleotides. While TSN-mediated degradation of either protein-free or AGO2-loaded miRNAs does not require the ATP-dependent RNA helicase UPF1 in vitro, we report here that cellular TumiD requires UPF1. Results from experiments using AGO2-loaded miRNAs in duplex with target mRNAs indicate that UPF1 can dissociate miRNAs from their mRNA targets, making the miRNAs susceptible to TumiD. miR-seq (deep sequencing of miRNAs) data reveal that the degradation of ∼50% of candidate TumiD targets in T24 human urinary bladder cancer cells is augmented by UPF1. We illustrate the physiological relevance by demonstrating that UPF1-augmented TumiD promotes the invasion of T24 cells in part by degrading anti-invasive miRNAs so as to up-regulate the expression of proinvasive proteins."xsd:string |
| http://purl.uniprot.org/citations/28827400 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.303537.117"xsd:string |
| http://purl.uniprot.org/citations/28827400 | http://purl.uniprot.org/core/author | "Miyoshi K."xsd:string |
| http://purl.uniprot.org/citations/28827400 | http://purl.uniprot.org/core/author | "Elbarbary R.A."xsd:string |
| http://purl.uniprot.org/citations/28827400 | http://purl.uniprot.org/core/author | "Maquat L.E."xsd:string |
| http://purl.uniprot.org/citations/28827400 | http://purl.uniprot.org/core/author | "Myers J.R."xsd:string |
| http://purl.uniprot.org/citations/28827400 | http://purl.uniprot.org/core/author | "Hedaya O."xsd:string |
| http://purl.uniprot.org/citations/28827400 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28827400 | http://purl.uniprot.org/core/name | "Genes Dev"xsd:string |
| http://purl.uniprot.org/citations/28827400 | http://purl.uniprot.org/core/pages | "1483-1493"xsd:string |
| http://purl.uniprot.org/citations/28827400 | http://purl.uniprot.org/core/title | "UPF1 helicase promotes TSN-mediated miRNA decay."xsd:string |
| http://purl.uniprot.org/citations/28827400 | http://purl.uniprot.org/core/volume | "31"xsd:string |
| http://purl.uniprot.org/citations/28827400 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28827400 |
| http://purl.uniprot.org/citations/28827400 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28827400 |
| http://purl.uniprot.org/uniprot/#_A0A024R7L5-mappedCitation-28827400 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28827400 |
| http://purl.uniprot.org/uniprot/#_A0A059X4U2-mappedCitation-28827400 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28827400 |
| http://purl.uniprot.org/uniprot/#_A0A059XAJ5-mappedCitation-28827400 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28827400 |
| http://purl.uniprot.org/uniprot/#_A0A059XAL2-mappedCitation-28827400 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28827400 |
| http://purl.uniprot.org/uniprot/#_A0A059XAL6-mappedCitation-28827400 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28827400 |
| http://purl.uniprot.org/uniprot/#_A0A059XAM1-mappedCitation-28827400 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28827400 |
| http://purl.uniprot.org/uniprot/#_A0A059XBJ1-mappedCitation-28827400 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28827400 |
| http://purl.uniprot.org/uniprot/#_A0A059XBJ6-mappedCitation-28827400 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28827400 |
| http://purl.uniprot.org/uniprot/#_A0A059XG67-mappedCitation-28827400 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28827400 |
| http://purl.uniprot.org/uniprot/#_A0A059XG73-mappedCitation-28827400 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28827400 |