| http://purl.uniprot.org/citations/28827518 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28827518 | http://www.w3.org/2000/01/rdf-schema#comment | "Graft-vs.-host disease (GvHD) is a major complication of allogenic hematopoietic stem-cell(HSC) transplantation. GvHD is associated with loss of endothelial thrombomodulin, but the relevance of this for the adaptive immune response to transplanted HSCs remains unknown. Here we show that the protease-activated protein C (aPC), which is generated by thrombomodulin, ameliorates GvHD aPC restricts allogenic T-cell activation via the protease activated receptor (PAR)2/PAR3 heterodimer on regulatory T-cells (Tregs, CD4+FOXP3+). Preincubation of pan T-cells with aPC prior to transplantation increases the frequency of Tregs and protects from GvHD. Preincubation of human T-cells (HLA-DR4-CD4+) with aPC prior to transplantation into humanized (NSG-AB°DR4) mice ameliorates graft-vs.-host disease. The protective effect of aPC on GvHD does not compromise the graft vs. leukaemia effect in two independent tumor cell models. Ex vivo preincubation of T-cells with aPC, aPC-based therapies, or targeting PAR2/PAR3 on T-cells may provide a safe and effective approach to mitigate GvHD.Graft-vs.-host disease is a complication of allogenic hematopoietic stem cell transplantation, and is associated with endothelial dysfunction. Here the authors show that activated protein C signals via PAR2/PAR3 to expand Treg cells, mitigating the disease in mice."xsd:string |
| http://purl.uniprot.org/citations/28827518 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-017-00169-4"xsd:string |
| http://purl.uniprot.org/citations/28827518 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
| http://purl.uniprot.org/citations/28827518 | http://purl.uniprot.org/core/author | "Gupta D."xsd:string |
| http://purl.uniprot.org/citations/28827518 | http://purl.uniprot.org/core/author | "Naumann M."xsd:string |
| http://purl.uniprot.org/citations/28827518 | http://purl.uniprot.org/core/author | "Fischer T."xsd:string |
| http://purl.uniprot.org/citations/28827518 | http://purl.uniprot.org/core/author | "Schraven B."xsd:string |
| http://purl.uniprot.org/citations/28827518 | http://purl.uniprot.org/core/author | "Luft T."xsd:string |
| http://purl.uniprot.org/citations/28827518 | http://purl.uniprot.org/core/author | "Kohli S."xsd:string |
| http://purl.uniprot.org/citations/28827518 | http://purl.uniprot.org/core/author | "Kalinski T."xsd:string |
| http://purl.uniprot.org/citations/28827518 | http://purl.uniprot.org/core/author | "Huehn J."xsd:string |
| http://purl.uniprot.org/citations/28827518 | http://purl.uniprot.org/core/author | "Reinhold D."xsd:string |
| http://purl.uniprot.org/citations/28827518 | http://purl.uniprot.org/core/author | "Bock F."xsd:string |
| http://purl.uniprot.org/citations/28827518 | http://purl.uniprot.org/core/author | "Ranjan S."xsd:string |
| http://purl.uniprot.org/citations/28827518 | http://purl.uniprot.org/core/author | "Shahzad K."xsd:string |
| http://purl.uniprot.org/citations/28827518 | http://purl.uniprot.org/core/author | "Gadi I."xsd:string |
| http://purl.uniprot.org/citations/28827518 | http://purl.uniprot.org/core/author | "Isermann B."xsd:string |
| http://purl.uniprot.org/citations/28827518 | http://purl.uniprot.org/core/author | "Kahne T."xsd:string |
| http://purl.uniprot.org/citations/28827518 | http://purl.uniprot.org/core/author | "Zenclussen A.C."xsd:string |
| http://purl.uniprot.org/citations/28827518 | http://purl.uniprot.org/core/author | "Bank U."xsd:string |
| http://purl.uniprot.org/citations/28827518 | http://purl.uniprot.org/core/author | "Shaikh H."xsd:string |
| http://purl.uniprot.org/citations/28827518 | http://purl.uniprot.org/core/author | "Pierau M."xsd:string |
| http://purl.uniprot.org/citations/28827518 | http://purl.uniprot.org/core/author | "Goihl A."xsd:string |
| http://purl.uniprot.org/citations/28827518 | http://purl.uniprot.org/core/author | "Brunner-Weinzierl M."xsd:string |