| http://purl.uniprot.org/citations/28834754 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28834754 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28834754 | http://www.w3.org/2000/01/rdf-schema#comment | "DNA double-strand break (DSB) repair by homologous recombination (HR) is initiated by CtIP/MRN-mediated DNA end resection to maintain genome integrity. SAMHD1 is a dNTP triphosphohydrolase, which restricts HIV-1 infection, and mutations are associated with Aicardi-Goutières syndrome and cancer. We show that SAMHD1 has a dNTPase-independent function in promoting DNA end resection to facilitate DSB repair by HR. SAMHD1 deficiency or Vpx-mediated degradation causes hypersensitivity to DSB-inducing agents, and SAMHD1 is recruited to DSBs. SAMHD1 complexes with CtIP via a conserved C-terminal domain and recruits CtIP to DSBs to facilitate end resection and HR. Significantly, a cancer-associated mutant with impaired CtIP interaction, but not dNTPase-inactive SAMHD1, fails to rescue the end resection impairment of SAMHD1 depletion. Our findings define a dNTPase-independent function for SAMHD1 in HR-mediated DSB repair by facilitating CtIP accrual to promote DNA end resection, providing insight into how SAMHD1 promotes genome integrity."xsd:string |
| http://purl.uniprot.org/citations/28834754 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2017.08.008"xsd:string |
| http://purl.uniprot.org/citations/28834754 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2017.08.008"xsd:string |
| http://purl.uniprot.org/citations/28834754 | http://purl.uniprot.org/core/author | "Deng X."xsd:string |
| http://purl.uniprot.org/citations/28834754 | http://purl.uniprot.org/core/author | "Deng X."xsd:string |
| http://purl.uniprot.org/citations/28834754 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/28834754 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/28834754 | http://purl.uniprot.org/core/author | "Zhang H."xsd:string |
| http://purl.uniprot.org/citations/28834754 | http://purl.uniprot.org/core/author | "Zhang H."xsd:string |
| http://purl.uniprot.org/citations/28834754 | http://purl.uniprot.org/core/author | "Yu D.S."xsd:string |
| http://purl.uniprot.org/citations/28834754 | http://purl.uniprot.org/core/author | "Yu D.S."xsd:string |
| http://purl.uniprot.org/citations/28834754 | http://purl.uniprot.org/core/author | "Kim B."xsd:string |
| http://purl.uniprot.org/citations/28834754 | http://purl.uniprot.org/core/author | "Kim B."xsd:string |
| http://purl.uniprot.org/citations/28834754 | http://purl.uniprot.org/core/author | "Cejka P."xsd:string |
| http://purl.uniprot.org/citations/28834754 | http://purl.uniprot.org/core/author | "Cejka P."xsd:string |
| http://purl.uniprot.org/citations/28834754 | http://purl.uniprot.org/core/author | "Anand R."xsd:string |
| http://purl.uniprot.org/citations/28834754 | http://purl.uniprot.org/core/author | "Anand R."xsd:string |
| http://purl.uniprot.org/citations/28834754 | http://purl.uniprot.org/core/author | "Werner E."xsd:string |
| http://purl.uniprot.org/citations/28834754 | http://purl.uniprot.org/core/author | "Werner E."xsd:string |
| http://purl.uniprot.org/citations/28834754 | http://purl.uniprot.org/core/author | "Dynan W.S."xsd:string |
| http://purl.uniprot.org/citations/28834754 | http://purl.uniprot.org/core/author | "Dynan W.S."xsd:string |
| http://purl.uniprot.org/citations/28834754 | http://purl.uniprot.org/core/author | "Rothenberg E."xsd:string |
| http://purl.uniprot.org/citations/28834754 | http://purl.uniprot.org/core/author | "Rothenberg E."xsd:string |