| http://purl.uniprot.org/citations/28837617 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28837617 | http://www.w3.org/2000/01/rdf-schema#comment | "The GW182/TNRC6 family of proteins are central scaffolds that link microRNA-associated Argonaute proteins to the cytoplasmic decay machinery for targeted mRNA degradation processes. Although nuclear roles for the GW182/TNRC6 proteins are unknown, recent reports have demonstrated nucleocytoplasmic shuttling activity that utilises the importin-α and importin-β transport receptors for nuclear translocation. Here we describe the structure of mouse importin-α in complex with the TNRC6A nuclear localisation signal peptide. We further show that the interactions observed between TNRC6A and importin-α are conserved between mouse and human complexes. Our results highlight the ability of monopartite cNLS sequences to maximise contacts at the importin-α major binding site, as well as regions outside the main binding cavities."xsd:string |
| http://purl.uniprot.org/citations/28837617 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0183587"xsd:string |
| http://purl.uniprot.org/citations/28837617 | http://purl.uniprot.org/core/author | "Christie M."xsd:string |
| http://purl.uniprot.org/citations/28837617 | http://purl.uniprot.org/core/author | "Stewart A.G."xsd:string |
| http://purl.uniprot.org/citations/28837617 | http://purl.uniprot.org/core/author | "Chaston J.J."xsd:string |
| http://purl.uniprot.org/citations/28837617 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28837617 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/28837617 | http://purl.uniprot.org/core/pages | "e0183587"xsd:string |
| http://purl.uniprot.org/citations/28837617 | http://purl.uniprot.org/core/title | "Structural characterisation of TNRC6A nuclear localisation signal in complex with importin-alpha."xsd:string |
| http://purl.uniprot.org/citations/28837617 | http://purl.uniprot.org/core/volume | "12"xsd:string |
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