| http://purl.uniprot.org/citations/28841134 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28841134 | http://www.w3.org/2000/01/rdf-schema#comment | "Chromosome segregation requires robust interactions between the macromolecular kinetochore structure and dynamic microtubule polymers. A key outstanding question is how kinetochore-microtubule attachments are modulated to ensure that bi-oriented attachments are selectively stabilized and maintained. The Astrin-SKAP complex localizes preferentially to properly bi-oriented sister kinetochores, representing the final outer kinetochore component recruited prior to anaphase onset. Here, we reconstitute the 4-subunit Astrin-SKAP complex, including a novel MYCBP subunit. Our work demonstrates that the Astrin-SKAP complex contains separable kinetochore localization and microtubule binding domains. In addition, through cross-linking analysis in human cells and biochemical reconstitution, we show that the Astrin-SKAP complex binds synergistically to microtubules with the Ndc80 complex to form an integrated interface. We propose a model in which the Astrin-SKAP complex acts together with the Ndc80 complex to stabilize correctly formed kinetochore-microtubule interactions."xsd:string |
| http://purl.uniprot.org/citations/28841134 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.26866"xsd:string |
| http://purl.uniprot.org/citations/28841134 | http://purl.uniprot.org/core/author | "Kern D.M."xsd:string |
| http://purl.uniprot.org/citations/28841134 | http://purl.uniprot.org/core/author | "Cheeseman I.M."xsd:string |
| http://purl.uniprot.org/citations/28841134 | http://purl.uniprot.org/core/author | "Monda J.K."xsd:string |
| http://purl.uniprot.org/citations/28841134 | http://purl.uniprot.org/core/author | "Wilson-Kubalek E.M."xsd:string |
| http://purl.uniprot.org/citations/28841134 | http://purl.uniprot.org/core/author | "Su K.C."xsd:string |
| http://purl.uniprot.org/citations/28841134 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28841134 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/28841134 | http://purl.uniprot.org/core/pages | "e26866"xsd:string |
| http://purl.uniprot.org/citations/28841134 | http://purl.uniprot.org/core/title | "Astrin-SKAP complex reconstitution reveals its kinetochore interaction with microtubule-bound Ndc80."xsd:string |
| http://purl.uniprot.org/citations/28841134 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/28841134 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28841134 |
| http://purl.uniprot.org/citations/28841134 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28841134 |
| http://purl.uniprot.org/uniprot/#_A4FUA2-mappedCitation-28841134 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28841134 |
| http://purl.uniprot.org/uniprot/#_A8K031-mappedCitation-28841134 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28841134 |
| http://purl.uniprot.org/uniprot/#_A8K8N3-mappedCitation-28841134 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28841134 |
| http://purl.uniprot.org/uniprot/#_B4DP18-mappedCitation-28841134 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28841134 |
| http://purl.uniprot.org/uniprot/#_O14777-mappedCitation-28841134 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28841134 |
| http://purl.uniprot.org/uniprot/#_Q05DQ6-mappedCitation-28841134 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28841134 |
| http://purl.uniprot.org/uniprot/#_Q96R06-mappedCitation-28841134 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28841134 |
| http://purl.uniprot.org/uniprot/#_Q9Y448-mappedCitation-28841134 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28841134 |
| http://purl.uniprot.org/uniprot/#_V9GY01-mappedCitation-28841134 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28841134 |
| http://purl.uniprot.org/uniprot/A8K031 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28841134 |