| http://purl.uniprot.org/citations/28842245 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28842245 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28842245 | http://www.w3.org/2000/01/rdf-schema#comment | "Fused in sarcoma (FUS) is an RNA binding protein that is involved in frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). To establish the common marmoset (Callithrix jacchus) as a model for FTLD, we generated a stereotaxic injection-based marmoset model of FUS-silencing. We designed shRNAs against the marmoset FUS gene and generated an AAV9 virus encoding the most effective shRNA against FUS (shFUS). The AAV encoding shFUS (AAV-shFUS) was introduced into the frontal cortex of young adult marmosets, whereas AAV encoding a control shRNA was injected into the contralateral side. We obtained approximately 70-80% silencing of FUS following AAV-shFUS injection. Interestingly, FUS-silencing provoked a proliferation of astrocytes and microglias. Since FTLD is characterized by various emotional deficits, it would be helpful to establish a marmoset model of FUS-silencing in various brain tissues for investigating the pathomechanism of higher cognitive and behavioral dysfunction."xsd:string |
| http://purl.uniprot.org/citations/28842245 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neures.2017.08.006"xsd:string |
| http://purl.uniprot.org/citations/28842245 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neures.2017.08.006"xsd:string |
| http://purl.uniprot.org/citations/28842245 | http://purl.uniprot.org/core/author | "Matsuzaki M."xsd:string |
| http://purl.uniprot.org/citations/28842245 | http://purl.uniprot.org/core/author | "Matsuzaki M."xsd:string |
| http://purl.uniprot.org/citations/28842245 | http://purl.uniprot.org/core/author | "Watanabe H."xsd:string |
| http://purl.uniprot.org/citations/28842245 | http://purl.uniprot.org/core/author | "Watanabe H."xsd:string |
| http://purl.uniprot.org/citations/28842245 | http://purl.uniprot.org/core/author | "Fujioka Y."xsd:string |
| http://purl.uniprot.org/citations/28842245 | http://purl.uniprot.org/core/author | "Fujioka Y."xsd:string |
| http://purl.uniprot.org/citations/28842245 | http://purl.uniprot.org/core/author | "Endo K."xsd:string |
| http://purl.uniprot.org/citations/28842245 | http://purl.uniprot.org/core/author | "Endo K."xsd:string |
| http://purl.uniprot.org/citations/28842245 | http://purl.uniprot.org/core/author | "Yamamori T."xsd:string |
| http://purl.uniprot.org/citations/28842245 | http://purl.uniprot.org/core/author | "Yamamori T."xsd:string |
| http://purl.uniprot.org/citations/28842245 | http://purl.uniprot.org/core/author | "Okado H."xsd:string |
| http://purl.uniprot.org/citations/28842245 | http://purl.uniprot.org/core/author | "Okado H."xsd:string |
| http://purl.uniprot.org/citations/28842245 | http://purl.uniprot.org/core/author | "Sobue G."xsd:string |
| http://purl.uniprot.org/citations/28842245 | http://purl.uniprot.org/core/author | "Sobue G."xsd:string |
| http://purl.uniprot.org/citations/28842245 | http://purl.uniprot.org/core/author | "Nambu A."xsd:string |
| http://purl.uniprot.org/citations/28842245 | http://purl.uniprot.org/core/author | "Nambu A."xsd:string |
| http://purl.uniprot.org/citations/28842245 | http://purl.uniprot.org/core/author | "Hatanaka N."xsd:string |
| http://purl.uniprot.org/citations/28842245 | http://purl.uniprot.org/core/author | "Hatanaka N."xsd:string |
| http://purl.uniprot.org/citations/28842245 | http://purl.uniprot.org/core/author | "Watakabe A."xsd:string |
| http://purl.uniprot.org/citations/28842245 | http://purl.uniprot.org/core/author | "Watakabe A."xsd:string |