| http://purl.uniprot.org/citations/28846091 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28846091 | http://www.w3.org/2000/01/rdf-schema#comment | "MicroRNA (miRNA) biogenesis is known to be modulated by a variety of RNA-binding proteins (RBPs), but in most cases, individual RBPs appear to influence the processing of a small subset of target miRNAs. Here, we report that the RNA-binding NONO-PSF heterodimer binds a large number of expressed pri-miRNAs in HeLa cells to globally enhance pri-miRNA processing by the Drosha-DGCR8 Microprocessor. NONO and PSF are key components of paraspeckles organized by the long noncoding RNA (lncRNA) NEAT1. We further demonstrate that NEAT1 also has a profound effect on global pri-miRNA processing. Mechanistic dissection reveals that NEAT1 broadly interacts with the NONO-PSF heterodimer as well as many other RBPs and that multiple RNA segments in NEAT1, including a 'pseudo pri-miRNA' near its 3' end, help attract the Microprocessor. These findings suggest a 'bird nest' model in which an lncRNA orchestrates efficient processing of potentially an entire class of small noncoding RNAs in the nucleus."xsd:string |
| http://purl.uniprot.org/citations/28846091 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsmb.3455"xsd:string |
| http://purl.uniprot.org/citations/28846091 | http://purl.uniprot.org/core/author | "Chen G."xsd:string |
| http://purl.uniprot.org/citations/28846091 | http://purl.uniprot.org/core/author | "Jiang L."xsd:string |
| http://purl.uniprot.org/citations/28846091 | http://purl.uniprot.org/core/author | "Li H."xsd:string |
| http://purl.uniprot.org/citations/28846091 | http://purl.uniprot.org/core/author | "Shao C."xsd:string |
| http://purl.uniprot.org/citations/28846091 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/28846091 | http://purl.uniprot.org/core/author | "Zhou J."xsd:string |
| http://purl.uniprot.org/citations/28846091 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/28846091 | http://purl.uniprot.org/core/author | "Zhou Y."xsd:string |
| http://purl.uniprot.org/citations/28846091 | http://purl.uniprot.org/core/author | "Yang B."xsd:string |
| http://purl.uniprot.org/citations/28846091 | http://purl.uniprot.org/core/author | "Yeo G.W."xsd:string |
| http://purl.uniprot.org/citations/28846091 | http://purl.uniprot.org/core/author | "Fu X.D."xsd:string |
| http://purl.uniprot.org/citations/28846091 | http://purl.uniprot.org/core/author | "Gou L.T."xsd:string |
| http://purl.uniprot.org/citations/28846091 | http://purl.uniprot.org/core/author | "Wu Q.J."xsd:string |
| http://purl.uniprot.org/citations/28846091 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28846091 | http://purl.uniprot.org/core/name | "Nat Struct Mol Biol"xsd:string |
| http://purl.uniprot.org/citations/28846091 | http://purl.uniprot.org/core/pages | "816-824"xsd:string |
| http://purl.uniprot.org/citations/28846091 | http://purl.uniprot.org/core/title | "NEAT1 scaffolds RNA-binding proteins and the Microprocessor to globally enhance pri-miRNA processing."xsd:string |
| http://purl.uniprot.org/citations/28846091 | http://purl.uniprot.org/core/volume | "24"xsd:string |
| http://purl.uniprot.org/citations/28846091 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28846091 |
| http://purl.uniprot.org/citations/28846091 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28846091 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z4Z9-mappedCitation-28846091 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28846091 |
| http://purl.uniprot.org/uniprot/#_Q15559-mappedCitation-28846091 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28846091 |