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| http://purl.uniprot.org/citations/28848067 | http://www.w3.org/2000/01/rdf-schema#comment | "BAFF is a B cell survival and maturation factor implicated in the pathogenesis of systemic lupus erythematosus (SLE). In this in vitro study, we describe that soluble BAFF in combination with IL-2 and IL-21 is a T cell contact-independent inducer of human B cell proliferation, plasmablast differentiation, and IgG secretion from circulating CD27+ memory and memory-like CD27-IgD- double-negative (DN) B cells, but not CD27-IgD+ naive B cells. In contrast, soluble CD40L in combination with IL-2 and IL-21 induces these activities in both memory and naive B cells. Blood from healthy donors and SLE patients have similar circulating levels of IL-2, whereas SLE patients exhibit elevated BAFF and DN B cells and reduced IL-21. B cell differentiation transcription factors in memory, DN, and naive B cells in SLE show elevated levels of Aiolos, whereas Ikaros levels are unchanged. Treatment with CC-220, a modulator of the cullin ring ligase 4-cereblon E3 ubiquitin ligase complex, reduces Aiolos and Ikaros protein levels and BAFF- and CD40L-induced proliferation, plasmablast differentiation, and IgG secretion. The observation that the soluble factors BAFF, IL-2, and IL-21 induce memory and DN B cell activation and differentiation has implications for extrafollicular plasmablast development within inflamed tissue. Inhibition of B cell plasmablast differentiation by reduction of Aiolos and Ikaros may have utility in the treatment of SLE, where elevated levels of BAFF and Aiolos may prime CD27+ memory and DN memory-like B cells to become Ab-producing plasmablasts in the presence of BAFF and proinflammatory cytokines."xsd:string |
| http://purl.uniprot.org/citations/28848067 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1601725"xsd:string |
| http://purl.uniprot.org/citations/28848067 | http://purl.uniprot.org/core/author | "Nakayama Y."xsd:string |
| http://purl.uniprot.org/citations/28848067 | http://purl.uniprot.org/core/author | "Schafer P.H."xsd:string |
| http://purl.uniprot.org/citations/28848067 | http://purl.uniprot.org/core/author | "Hur E.M."xsd:string |
| http://purl.uniprot.org/citations/28848067 | http://purl.uniprot.org/core/author | "Ringheim G.E."xsd:string |
| http://purl.uniprot.org/citations/28848067 | http://purl.uniprot.org/core/author | "Kosek J."xsd:string |
| http://purl.uniprot.org/citations/28848067 | http://purl.uniprot.org/core/author | "Capone L."xsd:string |
| http://purl.uniprot.org/citations/28848067 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28848067 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/28848067 | http://purl.uniprot.org/core/pages | "2388-2407"xsd:string |
| http://purl.uniprot.org/citations/28848067 | http://purl.uniprot.org/core/title | "Aiolos Overexpression in Systemic Lupus Erythematosus B Cell Subtypes and BAFF-Induced Memory B Cell Differentiation Are Reduced by CC-220 Modulation of Cereblon Activity."xsd:string |
| http://purl.uniprot.org/citations/28848067 | http://purl.uniprot.org/core/volume | "199"xsd:string |
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