| http://purl.uniprot.org/citations/28854365 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28854365 | http://www.w3.org/2000/01/rdf-schema#comment | "Although Netos are considered auxiliary subunits critical for kainate receptor (KAR) function, direct evidence for their regulation of native KARs is limited. Because Neto KAR regulation is GluK subunit/Neto isoform specific, such regulation must be determined in cell-type-specific contexts. We demonstrate Neto1/2 expression in somatostatin (SOM)-, cholecystokinin/cannabinoid receptor 1 (CCK/CB1)-, and parvalbumin (PV)-containing interneurons. KAR-mediated excitation of these interneurons is contingent upon Neto1 because kainate yields comparable effects in Neto2 knockouts and wild-types but fails to excite interneurons or recruit inhibition in Neto1 knockouts. In contrast, presynaptic KARs in CCK/CB1 interneurons are dually regulated by both Neto1 and Neto2. Neto association promotes tonic presynaptic KAR activation, dampening CCK/CB1 interneuron output, and loss of this brake in Neto mutants profoundly increases CCK/CB1 interneuron-mediated inhibition. Our results confirm that Neto1 regulates endogenous somatodendritic KARs in diverse interneurons and demonstrate Neto regulation of presynaptic KARs in mature inhibitory presynaptic terminals."xsd:string |
| http://purl.uniprot.org/citations/28854365 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2017.08.017"xsd:string |
| http://purl.uniprot.org/citations/28854365 | http://purl.uniprot.org/core/author | "McInnes R.R."xsd:string |
| http://purl.uniprot.org/citations/28854365 | http://purl.uniprot.org/core/author | "Yuan X."xsd:string |
| http://purl.uniprot.org/citations/28854365 | http://purl.uniprot.org/core/author | "Hunt S."xsd:string |
| http://purl.uniprot.org/citations/28854365 | http://purl.uniprot.org/core/author | "Fang C."xsd:string |
| http://purl.uniprot.org/citations/28854365 | http://purl.uniprot.org/core/author | "Salter M.W."xsd:string |
| http://purl.uniprot.org/citations/28854365 | http://purl.uniprot.org/core/author | "McBain C.J."xsd:string |
| http://purl.uniprot.org/citations/28854365 | http://purl.uniprot.org/core/author | "Pelkey K.A."xsd:string |
| http://purl.uniprot.org/citations/28854365 | http://purl.uniprot.org/core/author | "Fisahn A."xsd:string |
| http://purl.uniprot.org/citations/28854365 | http://purl.uniprot.org/core/author | "Chittajallu R."xsd:string |
| http://purl.uniprot.org/citations/28854365 | http://purl.uniprot.org/core/author | "Abebe D."xsd:string |
| http://purl.uniprot.org/citations/28854365 | http://purl.uniprot.org/core/author | "Mahadevan V."xsd:string |
| http://purl.uniprot.org/citations/28854365 | http://purl.uniprot.org/core/author | "Wyeth M.S."xsd:string |
| http://purl.uniprot.org/citations/28854365 | http://purl.uniprot.org/core/author | "Johnston A.D."xsd:string |
| http://purl.uniprot.org/citations/28854365 | http://purl.uniprot.org/core/author | "Vargish G."xsd:string |
| http://purl.uniprot.org/citations/28854365 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28854365 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/28854365 | http://purl.uniprot.org/core/pages | "2156-2168"xsd:string |
| http://purl.uniprot.org/citations/28854365 | http://purl.uniprot.org/core/title | "Neto Auxiliary Subunits Regulate Interneuron Somatodendritic and Presynaptic Kainate Receptors to Control Network Inhibition."xsd:string |
| http://purl.uniprot.org/citations/28854365 | http://purl.uniprot.org/core/volume | "20"xsd:string |
| http://purl.uniprot.org/citations/28854365 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28854365 |
| http://purl.uniprot.org/citations/28854365 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28854365 |
| http://purl.uniprot.org/uniprot/#_A0A1W2P868-mappedCitation-28854365 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28854365 |