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http://purl.uniprot.org/citations/28856757http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/28856757http://www.w3.org/2000/01/rdf-schema#comment"

Problem

The level of CCL19 increased in the peritoneal fluid of women with endometriosis, but the precise mechanism of CCL19/CCR7 in the pathogenesis of endometriosis remains unknown.

Methods

ELISA and immunohistochemistry were performed to analyze CCL19/CCR7 expressions in peritoneal fluid and endometrium from women with endometriosis (n = 38) and controls (n = 32). Cell proliferation and transwell invasion assays were applied to detect proliferation and invasion of human endometrial stromal cells (ESCs). Expressions of Bcl2, MMP2, MMP9, and p-AKT/AKT were analyzed by Western blot.

Results

Peritoneal fluid concentration of CCL19 in patients with endometriosis was higher than that in controls. Those patients with moderate/severe endometriosis had significantly higher peritoneal fluid concentrations of CCL19 compared to those with minimal/mild endometriosis. Higher CCL19 and CCR7 were found in the endometrium with endometriosis compared to control. CCL19 significantly enhanced ESC proliferation and invasion through CCR7 via activating PI3K/Akt signal pathways. CCL19/CCR7 interaction significantly enhanced phosphorylation of Akt, Bcl2, MMP2, and MMP9 in ESCs.

Conclusion

These data indicate CCL19/CCR7 contributes to proliferation and invasion of ESCs, which are conducive to the pathogenesis of endometriosis through activating PI3K/Akt pathway."xsd:string
http://purl.uniprot.org/citations/28856757http://purl.org/dc/terms/identifier"doi:10.1111/aji.12744"xsd:string
http://purl.uniprot.org/citations/28856757http://purl.uniprot.org/core/author"Cai X."xsd:string
http://purl.uniprot.org/citations/28856757http://purl.uniprot.org/core/author"Wei W."xsd:string
http://purl.uniprot.org/citations/28856757http://purl.uniprot.org/core/author"Zhao J."xsd:string
http://purl.uniprot.org/citations/28856757http://purl.uniprot.org/core/author"Tian F."xsd:string
http://purl.uniprot.org/citations/28856757http://purl.uniprot.org/core/author"Diao R."xsd:string
http://purl.uniprot.org/citations/28856757http://purl.uniprot.org/core/author"Duan Y.G."xsd:string
http://purl.uniprot.org/citations/28856757http://purl.uniprot.org/core/date"2017"xsd:gYear
http://purl.uniprot.org/citations/28856757http://purl.uniprot.org/core/name"Am J Reprod Immunol"xsd:string
http://purl.uniprot.org/citations/28856757http://purl.uniprot.org/core/title"CCL19/CCR7 contributes to the pathogenesis of endometriosis via PI3K/Akt pathway by regulating the proliferation and invasion of ESCs."xsd:string
http://purl.uniprot.org/citations/28856757http://purl.uniprot.org/core/volume"78"xsd:string
http://purl.uniprot.org/citations/28856757http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/28856757
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