| http://purl.uniprot.org/citations/28857429 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28857429 | http://www.w3.org/2000/01/rdf-schema#comment | "Tenascin-c is an extracellular matrix glycoprotein, the expression of which relates to the progression of atherosclerosis, myocardial infarction and heart failure. Annexin II acts as a cell surface receptor of tenascin-c. This study aimed to delineate the role of tenascin-c and annexin II in macrophages presented in atherosclerotic plaque. Animal models with atherosclerotic lesions were established using ApoE-KO mice fed with high-cholesterol diet. The expression of tenascin-c and annexin II in atherosclerotic lesions was determined by qRT-PCR, Western blot and immunohistochemistry analysis. Raw 264.7 macrophages and human primary macrophages were exposed to 5, 10 and 15 μg/ml tenascin-c for 12 hrs. Cell migration as well as the proangiogenic ability of macrophages was examined. Additionally, annexin II expression was delineated in raw 264.7 macrophages under normal condition (20% O2 ) for 12 hrs or hypoxic condition (1% O2 ) for 6-12 hrs. The expression of tenascin-c and annexin II was markedly augmented in lesion aorta. Tenascin-c positively regulated macrophage migration, which was dependent on the expression of annexin II in macrophages. VEGF release from macrophages and endothelial tube induction by macrophage were boosted by tenascin-c and attenuated by annexin II blocking. Furthermore, tenascin-c activated Akt/NF-κB and ERK signalling through annexin II. Lastly, hypoxia conditioning remarkably facilitates annexin II expression in macrophages through hypoxia-inducible factor (HIF)-1α but not HIF-2α. In conclusion, tenascin-c promoted macrophage migration and VEGF expression through annexin II, the expression of which was modulated by HIF-1α."xsd:string |
| http://purl.uniprot.org/citations/28857429 | http://purl.org/dc/terms/identifier | "doi:10.1111/jcmm.13332"xsd:string |
| http://purl.uniprot.org/citations/28857429 | http://purl.uniprot.org/core/author | "Gao Y."xsd:string |
| http://purl.uniprot.org/citations/28857429 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/28857429 | http://purl.uniprot.org/core/author | "Wang Z."xsd:string |
| http://purl.uniprot.org/citations/28857429 | http://purl.uniprot.org/core/author | "Xie X."xsd:string |
| http://purl.uniprot.org/citations/28857429 | http://purl.uniprot.org/core/author | "Xu Z."xsd:string |
| http://purl.uniprot.org/citations/28857429 | http://purl.uniprot.org/core/author | "Feng J."xsd:string |
| http://purl.uniprot.org/citations/28857429 | http://purl.uniprot.org/core/author | "Han L."xsd:string |
| http://purl.uniprot.org/citations/28857429 | http://purl.uniprot.org/core/author | "Xue J."xsd:string |
| http://purl.uniprot.org/citations/28857429 | http://purl.uniprot.org/core/author | "Wei Q."xsd:string |
| http://purl.uniprot.org/citations/28857429 | http://purl.uniprot.org/core/author | "Cao K."xsd:string |
| http://purl.uniprot.org/citations/28857429 | http://purl.uniprot.org/core/author | "Lan T."xsd:string |
| http://purl.uniprot.org/citations/28857429 | http://purl.uniprot.org/core/author | "Shan F."xsd:string |
| http://purl.uniprot.org/citations/28857429 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/28857429 | http://purl.uniprot.org/core/name | "J Cell Mol Med"xsd:string |
| http://purl.uniprot.org/citations/28857429 | http://purl.uniprot.org/core/pages | "429-438"xsd:string |
| http://purl.uniprot.org/citations/28857429 | http://purl.uniprot.org/core/title | "Tenascin-c renders a proangiogenic phenotype in macrophage via annexin II."xsd:string |
| http://purl.uniprot.org/citations/28857429 | http://purl.uniprot.org/core/volume | "22"xsd:string |
| http://purl.uniprot.org/citations/28857429 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28857429 |
| http://purl.uniprot.org/citations/28857429 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28857429 |
| http://purl.uniprot.org/uniprot/#_D3YHM4-mappedCitation-28857429 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28857429 |
| http://purl.uniprot.org/uniprot/#_Q15566-mappedCitation-28857429 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28857429 |
| http://purl.uniprot.org/uniprot/#_B0V2N5-mappedCitation-28857429 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28857429 |