| http://purl.uniprot.org/citations/2885918 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2885918 | http://www.w3.org/2000/01/rdf-schema#comment | "A polygenic basis for susceptibility to insulin-dependent diabetes in nonobese diabetic (NOD) mice has been established by outcross to a related inbred strain, nonobese normal (NON). Analysis of first and second backcross progeny has shown that at least three recessive genes are required for development of overt diabetes. One, Idd-1s, is tightly linked to the H-2K locus on chromosome 17; another, Idd-2s, is localized proximal to the Thy-1/Alp-1 cluster on chromosome 9. Segregation of a third, Idd-3s, could be shown in a second backcross. Neither Idd-1s nor Idd-2s could individually be identified as the locus controlling insulitis; leukocytic infiltrates in pancreas were common in most asymptomatic BC1 mice. Both F1 and BC1 mice exhibited the unusually high percentage of splenic T lymphocytes characteristic of NOD, suggesting dominant inheritance of this trait. The polygenic control of diabetogenesis in NOD mice, in which a recessive gene linked to the major histocompatibility complex is but one of several controlling loci, suggests that similar polygenic interactions underlie this type of diabetes in humans."xsd:string |
| http://purl.uniprot.org/citations/2885918 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.2885918"xsd:string |
| http://purl.uniprot.org/citations/2885918 | http://purl.uniprot.org/core/author | "Prochazka M."xsd:string |
| http://purl.uniprot.org/citations/2885918 | http://purl.uniprot.org/core/author | "Leiter E.H."xsd:string |
| http://purl.uniprot.org/citations/2885918 | http://purl.uniprot.org/core/author | "Serreze D.V."xsd:string |
| http://purl.uniprot.org/citations/2885918 | http://purl.uniprot.org/core/author | "Coleman D.L."xsd:string |
| http://purl.uniprot.org/citations/2885918 | http://purl.uniprot.org/core/date | "1987"xsd:gYear |
| http://purl.uniprot.org/citations/2885918 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/2885918 | http://purl.uniprot.org/core/pages | "286-289"xsd:string |
| http://purl.uniprot.org/citations/2885918 | http://purl.uniprot.org/core/title | "Three recessive loci required for insulin-dependent diabetes in nonobese diabetic mice."xsd:string |
| http://purl.uniprot.org/citations/2885918 | http://purl.uniprot.org/core/volume | "237"xsd:string |
| http://purl.uniprot.org/citations/2885918 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/2885918 |
| http://purl.uniprot.org/citations/2885918 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/2885918 |
| http://purl.uniprot.org/uniprot/#_A0A0B4J1G3-mappedCitation-2885918 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/2885918 |
| http://purl.uniprot.org/uniprot/#_A0A1L1STX7-mappedCitation-2885918 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/2885918 |
| http://purl.uniprot.org/uniprot/#_K7WBQ4-mappedCitation-2885918 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/2885918 |
| http://purl.uniprot.org/uniprot/#_A0A482CGP7-mappedCitation-2885918 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/2885918 |
| http://purl.uniprot.org/uniprot/#_A0A494B9G2-mappedCitation-2885918 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/2885918 |
| http://purl.uniprot.org/uniprot/#_A0A494B9G8-mappedCitation-2885918 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/2885918 |
| http://purl.uniprot.org/uniprot/#_A0A494BA33-mappedCitation-2885918 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/2885918 |
| http://purl.uniprot.org/uniprot/#_A0A494BAT0-mappedCitation-2885918 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/2885918 |
| http://purl.uniprot.org/uniprot/#_O19449-mappedCitation-2885918 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/2885918 |
| http://purl.uniprot.org/uniprot/#_G3UXW2-mappedCitation-2885918 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/2885918 |
| http://purl.uniprot.org/uniprot/#_B6VGH4-mappedCitation-2885918 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/2885918 |