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http://purl.uniprot.org/citations/28861760http://www.w3.org/2000/01/rdf-schema#comment"

Objective

To evaluate the role and the molecular mechanism of miR-30d in non-small cell lung cancer (NSCLC).

Results

qRT-PCR was used to detect miR-30d expression in NSCLC tissues and cell lines. miR-30d was frequently down-regulated in NSCLC and its expression was associated with clinicopathological features of NSCLCC patients. Over-expression of miR-30d notably inhibited cell migration and invasion in NSCLC cell lines. miR-30d could negatively regulate Nuclear factor I B (NFIB) by directly targeting its 3'-UTR, which was confirmed by luciferase assay. NFIB also reversed miR-30d-mediated suppression on the migration and invasion in NSCLC cell lines.

Conclusion

miR-30d suppressed cell migration and invasion by directly targeting NFIB in NSCLC, and NFIB could partially abrogated the inhibition of biological functions by miR-30d."xsd:string
http://purl.uniprot.org/citations/28861760http://purl.org/dc/terms/identifier"doi:10.1007/s10529-017-2428-9"xsd:string
http://purl.uniprot.org/citations/28861760http://purl.uniprot.org/core/author"Cheng Z."xsd:string
http://purl.uniprot.org/citations/28861760http://purl.uniprot.org/core/author"Hou S."xsd:string
http://purl.uniprot.org/citations/28861760http://purl.uniprot.org/core/author"Wu Y."xsd:string
http://purl.uniprot.org/citations/28861760http://purl.uniprot.org/core/author"Zhang J."xsd:string
http://purl.uniprot.org/citations/28861760http://purl.uniprot.org/core/author"Yuan M."xsd:string
http://purl.uniprot.org/citations/28861760http://purl.uniprot.org/core/date"2017"xsd:gYear
http://purl.uniprot.org/citations/28861760http://purl.uniprot.org/core/name"Biotechnol Lett"xsd:string
http://purl.uniprot.org/citations/28861760http://purl.uniprot.org/core/pages"1827-1834"xsd:string
http://purl.uniprot.org/citations/28861760http://purl.uniprot.org/core/title"Non-small cell lung cancer: miR-30d suppresses tumor invasion and migration by directly targeting NFIB."xsd:string
http://purl.uniprot.org/citations/28861760http://purl.uniprot.org/core/volume"39"xsd:string
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