| http://purl.uniprot.org/citations/28863969 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28863969 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin-7 is a cytokine essential for T cell homeostasis. IL-7 binds to cellular IL-7 receptors in competition with a soluble form of the receptor (sIL-7Rα). We hypothesized that altered sIL-7Rα levels may cause adverse outcomes in patients undergoing HSCT. In parallel, we investigated the impact of the IL-7Rα SNP rs6897932, which has been associated with release of IL-7R. The sIL-7Rα levels decreased during HSCT (from 114ng/ml before to 48ng/ml at day +14 (P<0.0001)). This pattern was inversely mirrored by IL-7. The IL-7/sIL-7Rα ratio at day +14 was significantly higher in patients developing grades II-IV aGVHD (OR=4.3, P=0.026). Furthermore, donor carriage of the rs6897932 T allele was associated with reduced sIL-7Rα levels, increased risk of grades II-IV aGVHD (OR=2.4, P=0.055) and increased transplant-related mortality (CC=4.5%, CT=21.4% and TT=27.3%, P=0.0037). In conclusion, this study suggests an impact of sIL-7Rα levels and rs6897932 donor genotype on alloreactivity and outcome after HSCT."xsd:string |
| http://purl.uniprot.org/citations/28863969 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.clim.2017.08.015"xsd:string |
| http://purl.uniprot.org/citations/28863969 | http://purl.uniprot.org/core/author | "Muller K."xsd:string |
| http://purl.uniprot.org/citations/28863969 | http://purl.uniprot.org/core/author | "Christensen I.J."xsd:string |
| http://purl.uniprot.org/citations/28863969 | http://purl.uniprot.org/core/author | "Ryder L.P."xsd:string |
| http://purl.uniprot.org/citations/28863969 | http://purl.uniprot.org/core/author | "Faucher S."xsd:string |
| http://purl.uniprot.org/citations/28863969 | http://purl.uniprot.org/core/author | "Yakoub-Agha I."xsd:string |
| http://purl.uniprot.org/citations/28863969 | http://purl.uniprot.org/core/author | "Shamim Z."xsd:string |
| http://purl.uniprot.org/citations/28863969 | http://purl.uniprot.org/core/author | "Decker W."xsd:string |
| http://purl.uniprot.org/citations/28863969 | http://purl.uniprot.org/core/author | "Thiant S."xsd:string |
| http://purl.uniprot.org/citations/28863969 | http://purl.uniprot.org/core/author | "Kielsen K."xsd:string |
| http://purl.uniprot.org/citations/28863969 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/28863969 | http://purl.uniprot.org/core/name | "Clin Immunol"xsd:string |
| http://purl.uniprot.org/citations/28863969 | http://purl.uniprot.org/core/pages | "26-32"xsd:string |
| http://purl.uniprot.org/citations/28863969 | http://purl.uniprot.org/core/title | "Soluble Interleukin-7 receptor levels and risk of acute graft-versus-host disease after allogeneic haematopoietic stem cell transplantation."xsd:string |
| http://purl.uniprot.org/citations/28863969 | http://purl.uniprot.org/core/volume | "187"xsd:string |
| http://purl.uniprot.org/citations/28863969 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28863969 |
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| http://purl.uniprot.org/uniprot/#_P16871-mappedCitation-28863969 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28863969 |
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