| http://purl.uniprot.org/citations/28864471 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28864471 | http://www.w3.org/2000/01/rdf-schema#comment | "Peripheral tolerance mechanisms exist to prevent autoimmune destruction by self-reactive T cells that escape thymic deletion. Dominant tolerance imposed by CD4+Foxp3+ T regulatory cells can actively control autoaggressive T cell responses. Tolerance mechanisms that act endogenous to the T cell also exist. These mechanisms include T cell inactivation (anergy) and deletion. A major difference between anergic T cells and T cells undergoing peripheral deletion is the capacity of the latter to still signal through MAPKs upon TCR stimulation, suggesting these signals may be required for T deletion. In this study, we used several different models of CD8 T cell deletion to investigate the contribution of MAPK activation. Using chemical inhibitors, we established that inhibition of p38, but not ERK or JNK, rescue T cells from undergoing peripheral deletion both in vitro and in vivo. Using T cell-specific murine lines genetically altered in expression of p38α, and mice in which p38α was deleted only in CD11c-expressing cells, we surprisingly found that CD8 T cell-intrinsic p38α activation was not responsible for increased survival, but rather that inhibition of p38α in the Ag-presenting dendritic cells prevented CD8 T cell deletion."xsd:string |
| http://purl.uniprot.org/citations/28864471 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1700427"xsd:string |
| http://purl.uniprot.org/citations/28864471 | http://purl.uniprot.org/core/author | "Lin X."xsd:string |
| http://purl.uniprot.org/citations/28864471 | http://purl.uniprot.org/core/author | "Cheung J."xsd:string |
| http://purl.uniprot.org/citations/28864471 | http://purl.uniprot.org/core/author | "Smith T."xsd:string |
| http://purl.uniprot.org/citations/28864471 | http://purl.uniprot.org/core/author | "Sherman L.A."xsd:string |
| http://purl.uniprot.org/citations/28864471 | http://purl.uniprot.org/core/author | "Lu B."xsd:string |
| http://purl.uniprot.org/citations/28864471 | http://purl.uniprot.org/core/author | "Marquardt K."xsd:string |
| http://purl.uniprot.org/citations/28864471 | http://purl.uniprot.org/core/author | "Mello M."xsd:string |
| http://purl.uniprot.org/citations/28864471 | http://purl.uniprot.org/core/author | "Verdeil G."xsd:string |
| http://purl.uniprot.org/citations/28864471 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28864471 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/28864471 | http://purl.uniprot.org/core/pages | "2713-2720"xsd:string |
| http://purl.uniprot.org/citations/28864471 | http://purl.uniprot.org/core/title | "Peripheral Deletion of CD8 T Cells Requires p38 MAPK in Cross-Presenting Dendritic Cells."xsd:string |
| http://purl.uniprot.org/citations/28864471 | http://purl.uniprot.org/core/volume | "199"xsd:string |
| http://purl.uniprot.org/citations/28864471 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28864471 |
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| http://purl.uniprot.org/uniprot/#_P22339-mappedCitation-28864471 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28864471 |