| http://purl.uniprot.org/citations/28864473 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28864473 | http://www.w3.org/2000/01/rdf-schema#comment | "Mucosal immunity to reinfection with a highly virulent virus requires the accumulation and persistence of memory CD8 T cells at the site of primary infection. These cells may derive from memory precursor effector cells (MPECs), which are distinct from short-lived effector cells that provide acute protection but are often destined to die. Using respiratory virus infection, we show that herpes virus entry mediator (HVEM; TNFRSF14), a member of the TNF receptor superfamily, provides key signals for MPEC persistence. HVEM-deficient CD8 T cells expanded normally but were skewed away from MPECs with resultant poor development of circulating and lung-resident memory cells. HVEM was selectively expressed on MPECs whereas MPECs deficient in HVEM failed to survive in adoptive transfer recipients. As a consequence, HVEM-deficient recipients failed to afford protection against respiratory reinfection with influenza virus. HVEM therefore represents a critical signal for MPECs and development of protective mucosal CD8 T cell memory."xsd:string |
| http://purl.uniprot.org/citations/28864473 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1700959"xsd:string |
| http://purl.uniprot.org/citations/28864473 | http://purl.uniprot.org/core/author | "Song J."xsd:string |
| http://purl.uniprot.org/citations/28864473 | http://purl.uniprot.org/core/author | "Desai P."xsd:string |
| http://purl.uniprot.org/citations/28864473 | http://purl.uniprot.org/core/author | "Ware C.F."xsd:string |
| http://purl.uniprot.org/citations/28864473 | http://purl.uniprot.org/core/author | "Croft M."xsd:string |
| http://purl.uniprot.org/citations/28864473 | http://purl.uniprot.org/core/author | "Salek-Ardakani S."xsd:string |
| http://purl.uniprot.org/citations/28864473 | http://purl.uniprot.org/core/author | "Thomas P.G."xsd:string |
| http://purl.uniprot.org/citations/28864473 | http://purl.uniprot.org/core/author | "Abboud G."xsd:string |
| http://purl.uniprot.org/citations/28864473 | http://purl.uniprot.org/core/author | "Stanfield J."xsd:string |
| http://purl.uniprot.org/citations/28864473 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28864473 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/28864473 | http://purl.uniprot.org/core/pages | "2968-2975"xsd:string |
| http://purl.uniprot.org/citations/28864473 | http://purl.uniprot.org/core/title | "HVEM Imprints Memory Potential on Effector CD8 T Cells Required for Protective Mucosal Immunity."xsd:string |
| http://purl.uniprot.org/citations/28864473 | http://purl.uniprot.org/core/volume | "199"xsd:string |
| http://purl.uniprot.org/citations/28864473 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28864473 |
| http://purl.uniprot.org/citations/28864473 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28864473 |
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| http://purl.uniprot.org/uniprot/#_A0A1W2P6M8-mappedCitation-28864473 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28864473 |
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| http://purl.uniprot.org/uniprot/#_Q80WM9-mappedCitation-28864473 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28864473 |
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| http://purl.uniprot.org/uniprot/#_Q71F55-mappedCitation-28864473 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28864473 |