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| http://purl.uniprot.org/citations/28865025 | http://www.w3.org/2000/01/rdf-schema#comment | "Although drebrin was first described in neurons, it is also expressed in cells of the immune system, such as T lymphocytes and mast cells. Another member of the drebrin family of proteins, mammalian actin-binding protein 1 (mAbp-1) is more widely expressed and plays important roles in the function of macrophages, polymorphonuclear neutrophils, and B lymphocytes. We will briefly discuss on the function of mAbp-1 and drebrin in immune cells with emphasis on T cells. Specifically, drebrin enables the immune responses of CD4+ T lymphocytes. T cells are activated after the recognition of an antigen presented by antigen-presenting cells through cognate cell-cell contacts called immunological synapses (IS). In CD4+ T cells, drebrin associates with the chemokine receptor CXCR4, and both molecules redistribute to the IS displaying similar dynamics. Through its interaction with CXCR4 and the actin cytoskeleton, drebrin regulates T cell activation. CD4+ T cells are one of the main targets for the human immunodeficiency virus (HIV)-1. This virus utilizes the IS structure to be transmitted to uninfected cells, forming cell-cell contacts called virological synapses (VS). Interestingly, drebrin negatively regulates HIV-1 infection of CD4+ T lymphocytes, by regulating actin polymerization at the VS."xsd:string |
| http://purl.uniprot.org/citations/28865025 | http://purl.org/dc/terms/identifier | "doi:10.1007/978-4-431-56550-5_15"xsd:string |
| http://purl.uniprot.org/citations/28865025 | http://purl.uniprot.org/core/author | "Sanchez-Madrid F."xsd:string |
| http://purl.uniprot.org/citations/28865025 | http://purl.uniprot.org/core/author | "Rocha-Perugini V."xsd:string |
| http://purl.uniprot.org/citations/28865025 | http://purl.uniprot.org/core/author | "Gordon-Alonso M."xsd:string |
| http://purl.uniprot.org/citations/28865025 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28865025 | http://purl.uniprot.org/core/name | "Adv Exp Med Biol"xsd:string |
| http://purl.uniprot.org/citations/28865025 | http://purl.uniprot.org/core/pages | "271-280"xsd:string |
| http://purl.uniprot.org/citations/28865025 | http://purl.uniprot.org/core/title | "Role of Drebrin at the Immunological Synapse."xsd:string |
| http://purl.uniprot.org/citations/28865025 | http://purl.uniprot.org/core/volume | "1006"xsd:string |
| http://purl.uniprot.org/citations/28865025 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28865025 |
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