| http://purl.uniprot.org/citations/28866095 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28866095 | http://www.w3.org/2000/01/rdf-schema#comment | "CRLF2-rearrangements (CRLF2-r) occur frequently in Ph-like B-ALL, a high-risk ALL sub-type characterized by a signaling profile similar to Ph + ALL, however accumulating evidence indicates genetic heterogeneity within CRLF2-r ALL. We performed thorough genomic characterization of 35 CRLF2-r cases (P2RY8-CRLF2 n = 18; IGH-CRLF2 n = 17). Activating JAK2 mutations were present in 34% of patients, and a CRLF2-F232C mutation was identified in an additional 17%. IKZF1 deletions were detected in 63% of cases. The majority of patients (26/35) classified as Ph-like, and these were characterized by significantly higher levels of MUC4, GPR110 and IL2RA/CD25. In addition, Ph-like CRLF2-r samples were significantly enriched for IKZF1 deletions, JAK2/CRLF2 mutations and increased expression of JAK/STAT target genes (CISH, SOCS1), suggesting that mutation-driven CRLF2/JAK2 activation is more frequent in this sub-group. Less is known about the genomics of CRLF2-r cases lacking JAK2-pathway mutations, but KRAS/NRAS mutations were identified in 4/9 non-Ph-like samples. This work highlights the heterogeneity of secondary lesions which may arise and influence intracellular-pathway activation in CRLF2-r patients, and importantly presents distinct therapeutic targets within a group of patients harboring identical primary translocations, for whom efficient directed therapies are currently lacking."xsd:string |
| http://purl.uniprot.org/citations/28866095 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.canlet.2017.08.034"xsd:string |
| http://purl.uniprot.org/citations/28866095 | http://purl.uniprot.org/core/author | "Moore S."xsd:string |
| http://purl.uniprot.org/citations/28866095 | http://purl.uniprot.org/core/author | "Osborn M."xsd:string |
| http://purl.uniprot.org/citations/28866095 | http://purl.uniprot.org/core/author | "White D.L."xsd:string |
| http://purl.uniprot.org/citations/28866095 | http://purl.uniprot.org/core/author | "Hughes T.P."xsd:string |
| http://purl.uniprot.org/citations/28866095 | http://purl.uniprot.org/core/author | "McClure B.J."xsd:string |
| http://purl.uniprot.org/citations/28866095 | http://purl.uniprot.org/core/author | "Sutton R."xsd:string |
| http://purl.uniprot.org/citations/28866095 | http://purl.uniprot.org/core/author | "Kok C.H."xsd:string |
| http://purl.uniprot.org/citations/28866095 | http://purl.uniprot.org/core/author | "Revesz T."xsd:string |
| http://purl.uniprot.org/citations/28866095 | http://purl.uniprot.org/core/author | "Heatley S.L."xsd:string |
| http://purl.uniprot.org/citations/28866095 | http://purl.uniprot.org/core/author | "Dang P."xsd:string |
| http://purl.uniprot.org/citations/28866095 | http://purl.uniprot.org/core/author | "Yeung D."xsd:string |
| http://purl.uniprot.org/citations/28866095 | http://purl.uniprot.org/core/author | "Sadras T."xsd:string |
| http://purl.uniprot.org/citations/28866095 | http://purl.uniprot.org/core/author | "Moore A.S."xsd:string |
| http://purl.uniprot.org/citations/28866095 | http://purl.uniprot.org/core/author | "Venn N.C."xsd:string |
| http://purl.uniprot.org/citations/28866095 | http://purl.uniprot.org/core/author | "Galbraith K.M."xsd:string |
| http://purl.uniprot.org/citations/28866095 | http://purl.uniprot.org/core/author | "Muskovic W."xsd:string |
| http://purl.uniprot.org/citations/28866095 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28866095 | http://purl.uniprot.org/core/name | "Cancer Lett"xsd:string |
| http://purl.uniprot.org/citations/28866095 | http://purl.uniprot.org/core/pages | "92-101"xsd:string |
| http://purl.uniprot.org/citations/28866095 | http://purl.uniprot.org/core/title | "Differential expression of MUC4, GPR110 and IL2RA defines two groups of CRLF2-rearranged acute lymphoblastic leukemia patients with distinct secondary lesions."xsd:string |
| http://purl.uniprot.org/citations/28866095 | http://purl.uniprot.org/core/volume | "408"xsd:string |
| http://purl.uniprot.org/citations/28866095 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28866095 |