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| http://purl.uniprot.org/citations/28877471 | http://www.w3.org/2000/01/rdf-schema#comment | "Gene fusions are increasingly recognized as important cancer drivers. The KIF5B-RET gene has been identified as a primary driver in a subset of lung adenocarcinomas. Targeting human KIF5B-RET to epithelia in Drosophila directed multiple aspects of transformation, including hyperproliferation, epithelial-to-mesenchymal transition, invasion, and extension of striking invadopodia-like processes. The KIF5B-RET-transformed human bronchial cell line showed similar aspects of transformation, including invadopodia-like processes. Through a combination of genetic and biochemical studies, we demonstrate that the kinesin and kinase domains of KIF5B-RET act together to establish an emergent microtubule and RAB-vesicle-dependent RET-SRC-EGFR-FGFR signaling hub. We demonstrate that drugs designed to inhibit RET alone work poorly in KIF5B-RET-transformed cells. However, combining the RET inhibitor sorafenib with drugs that target EGFR, microtubules, or FGFR led to strong efficacy in both Drosophila and human cell line KIF5B-RET models. This work demonstrates the utility of exploring the full biology of fusions to identify rational therapeutic strategies."xsd:string |
| http://purl.uniprot.org/citations/28877471 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2017.08.037"xsd:string |
| http://purl.uniprot.org/citations/28877471 | http://purl.uniprot.org/core/author | "Das T.K."xsd:string |
| http://purl.uniprot.org/citations/28877471 | http://purl.uniprot.org/core/author | "Cagan R.L."xsd:string |
| http://purl.uniprot.org/citations/28877471 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28877471 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/28877471 | http://purl.uniprot.org/core/pages | "2368-2383"xsd:string |
| http://purl.uniprot.org/citations/28877471 | http://purl.uniprot.org/core/title | "KIF5B-RET Oncoprotein Signals through a Multi-kinase Signaling Hub."xsd:string |
| http://purl.uniprot.org/citations/28877471 | http://purl.uniprot.org/core/volume | "20"xsd:string |
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