| http://purl.uniprot.org/citations/28880489 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28880489 | http://www.w3.org/2000/01/rdf-schema#comment | "Studies have shown that miR-4317 is dysregulated in tumor, but the biologic role of miR-4317 in tumor development and progression remains unknown. The present study aimed to investigate the role of miR-4317 in human gastric cancer. Quantitative real-time PCR was used to quantify miR-4317 expression levels in clinical gastric cancer specimens and cell lines. MTT, colony formation and cell cycle assays were performed to identify the contributions of miR-4317 to cell proliferation in gastric cancer cell lines. The results showed that miR-4317 was significantly decreased in 17 clinical gastric cancer specimens compared with adjacent non-tumor stomach tissues. Forced expression of miR-4317 suppressed gastric cancer cell proliferation and blocked S-G2/M transition. Bioinformatics and dual-luciferase reporter assays confirmed that ZNF322 is a direct target of miR-4317. Silencing ZNF322 recapitulated the cellular and molecular effects seen upon miR-4317 overexpression. These findings indicate that miR-4317 represses the proliferation of gastric cancer cell, at least in part, by targeting and suppressing ZNF322 and that it may serve as a therapeutic target for gastric cancer treatment."xsd:string |
| http://purl.uniprot.org/citations/28880489 | http://purl.org/dc/terms/identifier | "doi:10.1002/cbin.10870"xsd:string |
| http://purl.uniprot.org/citations/28880489 | http://purl.uniprot.org/core/author | "Hu X."xsd:string |
| http://purl.uniprot.org/citations/28880489 | http://purl.uniprot.org/core/author | "Huang C."xsd:string |
| http://purl.uniprot.org/citations/28880489 | http://purl.uniprot.org/core/author | "Wang X."xsd:string |
| http://purl.uniprot.org/citations/28880489 | http://purl.uniprot.org/core/author | "Zhang M."xsd:string |
| http://purl.uniprot.org/citations/28880489 | http://purl.uniprot.org/core/author | "Miao J."xsd:string |
| http://purl.uniprot.org/citations/28880489 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/28880489 | http://purl.uniprot.org/core/name | "Cell Biol Int"xsd:string |
| http://purl.uniprot.org/citations/28880489 | http://purl.uniprot.org/core/pages | "923-930"xsd:string |
| http://purl.uniprot.org/citations/28880489 | http://purl.uniprot.org/core/title | "miRNA-4317 suppresses human gastric cancer cell proliferation by targeting ZNF322."xsd:string |
| http://purl.uniprot.org/citations/28880489 | http://purl.uniprot.org/core/volume | "42"xsd:string |
| http://purl.uniprot.org/citations/28880489 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28880489 |
| http://purl.uniprot.org/citations/28880489 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28880489 |
| http://purl.uniprot.org/uniprot/#_Q6U7Q0-mappedCitation-28880489 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28880489 |
| http://purl.uniprot.org/uniprot/Q6U7Q0 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28880489 |