| http://purl.uniprot.org/citations/28882402 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28882402 | http://www.w3.org/2000/01/rdf-schema#comment | "Hypoblast/visceral endoderm assists in amniote nutrition, axial positioning and formation of the gut. Here, we provide evidence, currently limited to humans and non-human primates, that hypoblast is a purveyor of extraembryonic mesoderm in the mouse gastrula. Fate mapping a unique segment of axial extraembryonic visceral endoderm associated with the allantoic component of the primitive streak, and referred to as the "AX", revealed that visceral endoderm supplies the placentae with extraembryonic mesoderm. Exfoliation of the AX was dependent upon contact with the primitive streak, which modulated Hedgehog signaling. Resolution of the AX's epithelial-to-mesenchymal transition (EMT) by Hedgehog shaped the allantois into its characteristic projectile and individualized placental arterial vessels. A unique border cell separated the delaminating AX from the yolk sac blood islands which, situated beyond the limit of the streak, were not formed by an EMT. Over time, the AX became the hindgut lip, which contributed extensively to the posterior interface, including both embryonic and extraembryonic tissues. The AX, in turn, imparted antero-posterior (A-P) polarity on the primitive streak and promoted its elongation and differentiation into definitive endoderm. Results of heterotopic grafting supported mutually interactive functions of the AX and primitive streak, showing that together, they self-organized into a complete version of the fetal-placental interface, forming an elongated structure that exhibited A-P polarity and was composed of the allantois, an AX-derived rod-like axial extension reminiscent of the embryonic notochord, the placental arterial vasculature and visceral endoderm/hindgut."xsd:string |
| http://purl.uniprot.org/citations/28882402 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ydbio.2017.08.026"xsd:string |
| http://purl.uniprot.org/citations/28882402 | http://purl.uniprot.org/core/author | "Rodriguez A.M."xsd:string |
| http://purl.uniprot.org/citations/28882402 | http://purl.uniprot.org/core/author | "Downs K.M."xsd:string |
| http://purl.uniprot.org/citations/28882402 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28882402 | http://purl.uniprot.org/core/name | "Dev Biol"xsd:string |
| http://purl.uniprot.org/citations/28882402 | http://purl.uniprot.org/core/pages | "98-124"xsd:string |
| http://purl.uniprot.org/citations/28882402 | http://purl.uniprot.org/core/title | "Visceral endoderm and the primitive streak interact to build the fetal-placental interface of the mouse gastrula."xsd:string |
| http://purl.uniprot.org/citations/28882402 | http://purl.uniprot.org/core/volume | "432"xsd:string |
| http://purl.uniprot.org/citations/28882402 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28882402 |
| http://purl.uniprot.org/citations/28882402 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28882402 |
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| http://purl.uniprot.org/uniprot/#_B1ARA9-mappedCitation-28882402 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28882402 |