| http://purl.uniprot.org/citations/28884973 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28884973 | http://www.w3.org/2000/01/rdf-schema#comment | "HLA-A*31:01 and HLA-B*15:02 have been widely reported to confer genetic susceptibility to carbamazepine (CBZ)-induced severe cutaneous adverse reactions (SCARs). Accordingly, the screening for these alleles has been highly recommended to prevent SCAR prior to introducing CBZ therapy. Although a number of methods are available for screening of HLA-A*31:01 or HLA-B*15:02 alleles separately, developing an assay that can detect both these alleles would be more clinically practical, cost-effective and less time-consuming. Therefore, in this study, a multiplex polymerase chain reaction (PCR) using TaqMan Probe was designed and validated to be able to detect HLA-A*31:01 and HLA-B*15:02. In comparison with Luminex-SSO/SBT/SSB, the multiplex PCR assay for detection of HLA-A*31:01 and HLA-B*15:02 had a perfect agreement in the validation group of 125 samples. The method was able to detect the target genes at the DNA concentration of 0.037 ng/μL. The unit cost of this assay is less than $5 USD with total time of 110 minutes."xsd:string |
| http://purl.uniprot.org/citations/28884973 | http://purl.org/dc/terms/identifier | "doi:10.1111/tan.13143"xsd:string |
| http://purl.uniprot.org/citations/28884973 | http://purl.uniprot.org/core/author | "Chi H.C."xsd:string |
| http://purl.uniprot.org/citations/28884973 | http://purl.uniprot.org/core/author | "Fulton R."xsd:string |
| http://purl.uniprot.org/citations/28884973 | http://purl.uniprot.org/core/author | "Li J."xsd:string |
| http://purl.uniprot.org/citations/28884973 | http://purl.uniprot.org/core/author | "Vidal C."xsd:string |
| http://purl.uniprot.org/citations/28884973 | http://purl.uniprot.org/core/author | "Nguyen D.V."xsd:string |
| http://purl.uniprot.org/citations/28884973 | http://purl.uniprot.org/core/author | "Fernando S.L."xsd:string |
| http://purl.uniprot.org/citations/28884973 | http://purl.uniprot.org/core/author | "Do N.T.Q."xsd:string |
| http://purl.uniprot.org/citations/28884973 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28884973 | http://purl.uniprot.org/core/name | "HLA"xsd:string |
| http://purl.uniprot.org/citations/28884973 | http://purl.uniprot.org/core/pages | "335-342"xsd:string |
| http://purl.uniprot.org/citations/28884973 | http://purl.uniprot.org/core/title | "A novel multiplex polymerase chain reaction assay for detection of both HLA-A*31:01/HLA-B*15:02 alleles, which confer susceptibility to carbamazepine-induced severe cutaneous adverse reactions."xsd:string |
| http://purl.uniprot.org/citations/28884973 | http://purl.uniprot.org/core/volume | "90"xsd:string |
| http://purl.uniprot.org/citations/28884973 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28884973 |
| http://purl.uniprot.org/citations/28884973 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28884973 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C543-mappedCitation-28884973 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28884973 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C548-mappedCitation-28884973 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28884973 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C551-mappedCitation-28884973 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28884973 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C552-mappedCitation-28884973 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28884973 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DC98-mappedCitation-28884973 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28884973 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DCA0-mappedCitation-28884973 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28884973 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DCA1-mappedCitation-28884973 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28884973 |
| http://purl.uniprot.org/uniprot/#_A0A0G2R0N3-mappedCitation-28884973 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28884973 |