| http://purl.uniprot.org/citations/28885975 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28885975 | http://www.w3.org/2000/01/rdf-schema#comment | "Wnt5a-Ror signaling constitutes a developmental pathway crucial for embryonic tissue morphogenesis, reproduction and adult tissue regeneration, yet the molecular mechanisms by which the Wnt5a-Ror pathway mediates these processes are largely unknown. Using a proteomic screen, we identify the kinesin superfamily protein Kif26b as a downstream target of the Wnt5a-Ror pathway. Wnt5a-Ror, through a process independent of the canonical Wnt/β-catenin-dependent pathway, regulates the cellular stability of Kif26b by inducing its degradation via the ubiquitin-proteasome system. Through this mechanism, Kif26b modulates the migratory behavior of cultured mesenchymal cells in a Wnt5a-dependent manner. Genetic perturbation of Kif26b function in vivo caused embryonic axis malformations and depletion of primordial germ cells in the developing gonad, two phenotypes characteristic of disrupted Wnt5a-Ror signaling. These findings indicate that Kif26b links Wnt5a-Ror signaling to the control of morphogenetic cell and tissue behaviors in vertebrates and reveal a new role for regulated proteolysis in noncanonical Wnt5a-Ror signal transduction."xsd:string |
| http://purl.uniprot.org/citations/28885975 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.26509"xsd:string |
| http://purl.uniprot.org/citations/28885975 | http://purl.uniprot.org/core/author | "Choi S.S."xsd:string |
| http://purl.uniprot.org/citations/28885975 | http://purl.uniprot.org/core/author | "Gygi S.P."xsd:string |
| http://purl.uniprot.org/citations/28885975 | http://purl.uniprot.org/core/author | "Okada K."xsd:string |
| http://purl.uniprot.org/citations/28885975 | http://purl.uniprot.org/core/author | "Yamada S."xsd:string |
| http://purl.uniprot.org/citations/28885975 | http://purl.uniprot.org/core/author | "Kirschner M.W."xsd:string |
| http://purl.uniprot.org/citations/28885975 | http://purl.uniprot.org/core/author | "Greenberg M.E."xsd:string |
| http://purl.uniprot.org/citations/28885975 | http://purl.uniprot.org/core/author | "Kunz R.C."xsd:string |
| http://purl.uniprot.org/citations/28885975 | http://purl.uniprot.org/core/author | "Nishinakamura R."xsd:string |
| http://purl.uniprot.org/citations/28885975 | http://purl.uniprot.org/core/author | "Hu L.S."xsd:string |
| http://purl.uniprot.org/citations/28885975 | http://purl.uniprot.org/core/author | "Ho H.H."xsd:string |
| http://purl.uniprot.org/citations/28885975 | http://purl.uniprot.org/core/author | "Gujral T.S."xsd:string |
| http://purl.uniprot.org/citations/28885975 | http://purl.uniprot.org/core/author | "Jao L.E."xsd:string |
| http://purl.uniprot.org/citations/28885975 | http://purl.uniprot.org/core/author | "Laird D.J."xsd:string |
| http://purl.uniprot.org/citations/28885975 | http://purl.uniprot.org/core/author | "Susman M.W."xsd:string |
| http://purl.uniprot.org/citations/28885975 | http://purl.uniprot.org/core/author | "Hum J."xsd:string |
| http://purl.uniprot.org/citations/28885975 | http://purl.uniprot.org/core/author | "Cantu A.V."xsd:string |
| http://purl.uniprot.org/citations/28885975 | http://purl.uniprot.org/core/author | "Jong B.Y."xsd:string |
| http://purl.uniprot.org/citations/28885975 | http://purl.uniprot.org/core/author | "Karuna E.P."xsd:string |
| http://purl.uniprot.org/citations/28885975 | http://purl.uniprot.org/core/author | "Scales M.K."xsd:string |
| http://purl.uniprot.org/citations/28885975 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28885975 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/28885975 | http://purl.uniprot.org/core/pages | "e26509"xsd:string |