| http://purl.uniprot.org/citations/28885988 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28885988 | http://www.w3.org/2000/01/rdf-schema#comment | "ObjectivesA previous publication in Chinese leprosy patients showed that the HLA-B*13:01 allele is a strong genetic marker for dapsone-induced drug hypersensitivity reactions, however there are no data describing whether HLA-B*13:01 is a valid marker for prediction of dapsone-induced drug hypersensitivity reactions in other ethnicities or nonleprosy patients. The aim of this study is to investigate whether there is an association between HLA genotypes and dapsone-induced severe cutaneous adverse reactions (SCARs) in Thai nonleprosy patients.Patients and methodsHLA-B genotypes of 15 patients with dapsone-induced SCARs (11 drug reaction with eosinophilia and systemic symptoms, 4 Stevens-Johnson syndrome/toxic epidermal necrolysis), 29 control patients, and 986 subjects from the general Thai population were determined by the reverse PCR sequence-specific oligonucleotides probe.ResultsThe HLA-B*13:01 allele was significantly associated with dapsone-induced SCARs compared with dapsone-tolerant controls (odds ratio: 54.00, 95% confidence interval: 7.96-366.16, P=0.0001) and the general population (odds ratio: 26.11, 95% confidence interval: 7.27-93.75, P=0.0001). In addition, HLA-B*13:01 associated with dapsone-induced SJS-TEN (OR: 40.50, 95% confidence interval: 2.78-591.01, P=0.0070) and DRESS (OR: 60.75, 95% confidence interval: 7.44-496.18, P=0.0001).ConclusionThis study demonstrated an association between HLA-B*13:01 and dapsone-induced SCARs including Stevens-Johnson syndrome/toxic epidermal necrolysis and drug reaction with eosinophilia and systemic symptoms in nonleprosy patients. Moreover, these results suggest that the HLA-B*13:01 allele may be a useful genetic marker for prediction of dapsone-induced SCARs in Thai and Han-Chinese populations."xsd:string |
| http://purl.uniprot.org/citations/28885988 | http://purl.org/dc/terms/identifier | "doi:10.1097/fpc.0000000000000306"xsd:string |
| http://purl.uniprot.org/citations/28885988 | http://purl.uniprot.org/core/author | "Sukasem C."xsd:string |
| http://purl.uniprot.org/citations/28885988 | http://purl.uniprot.org/core/author | "Tempark T."xsd:string |
| http://purl.uniprot.org/citations/28885988 | http://purl.uniprot.org/core/author | "Tassaneeyakul W."xsd:string |
| http://purl.uniprot.org/citations/28885988 | http://purl.uniprot.org/core/author | "Klaewsongkram J."xsd:string |
| http://purl.uniprot.org/citations/28885988 | http://purl.uniprot.org/core/author | "Jantararoungtong T."xsd:string |
| http://purl.uniprot.org/citations/28885988 | http://purl.uniprot.org/core/author | "Koomdee N."xsd:string |
| http://purl.uniprot.org/citations/28885988 | http://purl.uniprot.org/core/author | "Mahakkanukrauh A."xsd:string |
| http://purl.uniprot.org/citations/28885988 | http://purl.uniprot.org/core/author | "Nakkam N."xsd:string |
| http://purl.uniprot.org/citations/28885988 | http://purl.uniprot.org/core/author | "Rerkpattanapipat T."xsd:string |
| http://purl.uniprot.org/citations/28885988 | http://purl.uniprot.org/core/author | "Saksit N."xsd:string |
| http://purl.uniprot.org/citations/28885988 | http://purl.uniprot.org/core/author | "Satapornpong P."xsd:string |
| http://purl.uniprot.org/citations/28885988 | http://purl.uniprot.org/core/author | "Pratoomwun J."xsd:string |
| http://purl.uniprot.org/citations/28885988 | http://purl.uniprot.org/core/author | "Rerknimitr P."xsd:string |
| http://purl.uniprot.org/citations/28885988 | http://purl.uniprot.org/core/author | "Suttisai S."xsd:string |
| http://purl.uniprot.org/citations/28885988 | http://purl.uniprot.org/core/author | "Wattanakrai P."xsd:string |
| http://purl.uniprot.org/citations/28885988 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28885988 | http://purl.uniprot.org/core/name | "Pharmacogenet Genomics"xsd:string |
| http://purl.uniprot.org/citations/28885988 | http://purl.uniprot.org/core/pages | "429-437"xsd:string |
| http://purl.uniprot.org/citations/28885988 | http://purl.uniprot.org/core/title | "Dapsone-induced severe cutaneous adverse drug reactions are strongly linked with HLA-B*13: 01 allele in the Thai population."xsd:string |
| http://purl.uniprot.org/citations/28885988 | http://purl.uniprot.org/core/volume | "27"xsd:string |
| http://purl.uniprot.org/citations/28885988 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28885988 |
| http://purl.uniprot.org/citations/28885988 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28885988 |