| http://purl.uniprot.org/citations/28888925 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28888925 | http://www.w3.org/2000/01/rdf-schema#comment | "CD4+ follicular helper T (Tfh) cells have been shown to be critical for the activation of germinal center (GC) B-cell responses. Similar to other infections, Plasmodium infection activates both GC as well as non-GC B cell responses. Here, we sought to explore whether Tfh cells and GC B cells are required to eliminate a Plasmodium infection. A CD4 T cell-targeted deletion of the gene that encodes Bcl6, the master transcription factor for the Tfh program, resulted in complete disruption of the Tfh response to Plasmodium chabaudi in C57BL/6 mice and consequent disruption of GC responses and IgG responses and the inability to eliminate the otherwise self-resolving chronic P. chabaudi infection. On the other hand, and contrary to previous observations in immunization and viral infection models, Signaling Lymphocyte Activation Molecule (SLAM)-Associated Protein (SAP)-deficient mice were able to activate Tfh cells, GC B cells, and IgG responses to the parasite. This study demonstrates the critical role for Tfh cells in controlling this systemic infection, and highlights differences in the signals required to activate GC B cell responses to this complex parasite compared with those of protein immunizations and viral infections. Therefore, these data are highly pertinent for designing malaria vaccines able to activate broadly protective B-cell responses."xsd:string |
| http://purl.uniprot.org/citations/28888925 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ebiom.2017.08.030"xsd:string |
| http://purl.uniprot.org/citations/28888925 | http://purl.uniprot.org/core/author | "Langhorne J."xsd:string |
| http://purl.uniprot.org/citations/28888925 | http://purl.uniprot.org/core/author | "McLaughlin S."xsd:string |
| http://purl.uniprot.org/citations/28888925 | http://purl.uniprot.org/core/author | "Hosking C."xsd:string |
| http://purl.uniprot.org/citations/28888925 | http://purl.uniprot.org/core/author | "Levy P."xsd:string |
| http://purl.uniprot.org/citations/28888925 | http://purl.uniprot.org/core/author | "Lewis M.D."xsd:string |
| http://purl.uniprot.org/citations/28888925 | http://purl.uniprot.org/core/author | "Nguyen M.P."xsd:string |
| http://purl.uniprot.org/citations/28888925 | http://purl.uniprot.org/core/author | "Perez-Mazliah D."xsd:string |
| http://purl.uniprot.org/citations/28888925 | http://purl.uniprot.org/core/author | "Tumwine I."xsd:string |
| http://purl.uniprot.org/citations/28888925 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28888925 | http://purl.uniprot.org/core/name | "EBioMedicine"xsd:string |
| http://purl.uniprot.org/citations/28888925 | http://purl.uniprot.org/core/pages | "216-230"xsd:string |
| http://purl.uniprot.org/citations/28888925 | http://purl.uniprot.org/core/title | "Follicular Helper T Cells are Essential for the Elimination of Plasmodium Infection."xsd:string |
| http://purl.uniprot.org/citations/28888925 | http://purl.uniprot.org/core/volume | "24"xsd:string |
| http://purl.uniprot.org/citations/28888925 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28888925 |
| http://purl.uniprot.org/citations/28888925 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28888925 |
| http://purl.uniprot.org/uniprot/#_B2RWI0-mappedCitation-28888925 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28888925 |
| http://purl.uniprot.org/uniprot/#_B7ZMX3-mappedCitation-28888925 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28888925 |
| http://purl.uniprot.org/uniprot/#_P41183-mappedCitation-28888925 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28888925 |
| http://purl.uniprot.org/uniprot/#_Q8CB25-mappedCitation-28888925 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28888925 |
| http://purl.uniprot.org/uniprot/#_Q8CD87-mappedCitation-28888925 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28888925 |
| http://purl.uniprot.org/uniprot/#_O88890-mappedCitation-28888925 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28888925 |
| http://purl.uniprot.org/uniprot/#_P21784-mappedCitation-28888925 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28888925 |