| http://purl.uniprot.org/citations/28890072 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28890072 | http://www.w3.org/2000/01/rdf-schema#comment | "The liver is the only organ in mammals that fully regenerates even after major injury. To identify orchestrators of this regenerative response, we performed quantitative large-scale proteomics analysis of cytoplasmic and nuclear fractions from normal versus regenerating mouse liver. Proteins of the ubiquitin-proteasome pathway were rapidly upregulated after two-third hepatectomy, with the ubiquitin ligase Nedd4-1 being a top hit. In vivo knockdown of Nedd4-1 in hepatocytes through nanoparticle-mediated delivery of small interfering RNA caused severe liver damage and inhibition of cell proliferation after hepatectomy, resulting in liver failure. Mechanistically, we demonstrate that Nedd4-1 is required for efficient internalization of major growth factor receptors involved in liver regeneration and their downstream mitogenic signaling. These results highlight the power of large-scale proteomics to identify key players in liver regeneration and the importance of posttranslational regulation of growth factor signaling in this process. Finally, they identify an essential function of Nedd4-1 in tissue repair."xsd:string |
| http://purl.uniprot.org/citations/28890072 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2017.07.025"xsd:string |
| http://purl.uniprot.org/citations/28890072 | http://purl.uniprot.org/core/author | "Graf R."xsd:string |
| http://purl.uniprot.org/citations/28890072 | http://purl.uniprot.org/core/author | "Kockmann T."xsd:string |
| http://purl.uniprot.org/citations/28890072 | http://purl.uniprot.org/core/author | "Meyer M."xsd:string |
| http://purl.uniprot.org/citations/28890072 | http://purl.uniprot.org/core/author | "Werner S."xsd:string |
| http://purl.uniprot.org/citations/28890072 | http://purl.uniprot.org/core/author | "Koteliansky V."xsd:string |
| http://purl.uniprot.org/citations/28890072 | http://purl.uniprot.org/core/author | "Anderson D.G."xsd:string |
| http://purl.uniprot.org/citations/28890072 | http://purl.uniprot.org/core/author | "Nanni P."xsd:string |
| http://purl.uniprot.org/citations/28890072 | http://purl.uniprot.org/core/author | "Bogorad R.L."xsd:string |
| http://purl.uniprot.org/citations/28890072 | http://purl.uniprot.org/core/author | "Auf dem Keller U."xsd:string |
| http://purl.uniprot.org/citations/28890072 | http://purl.uniprot.org/core/author | "Bohm F."xsd:string |
| http://purl.uniprot.org/citations/28890072 | http://purl.uniprot.org/core/author | "Padrissa-Altes S."xsd:string |
| http://purl.uniprot.org/citations/28890072 | http://purl.uniprot.org/core/author | "Speicher T."xsd:string |
| http://purl.uniprot.org/citations/28890072 | http://purl.uniprot.org/core/author | "Bachofner M."xsd:string |
| http://purl.uniprot.org/citations/28890072 | http://purl.uniprot.org/core/author | "Muzumdar S."xsd:string |
| http://purl.uniprot.org/citations/28890072 | http://purl.uniprot.org/core/author | "Derrer C.P."xsd:string |
| http://purl.uniprot.org/citations/28890072 | http://purl.uniprot.org/core/author | "Hurlimann F."xsd:string |
| http://purl.uniprot.org/citations/28890072 | http://purl.uniprot.org/core/author | "Kachaylo E."xsd:string |
| http://purl.uniprot.org/citations/28890072 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28890072 | http://purl.uniprot.org/core/name | "Dev Cell"xsd:string |
| http://purl.uniprot.org/citations/28890072 | http://purl.uniprot.org/core/pages | "616-625.e8"xsd:string |
| http://purl.uniprot.org/citations/28890072 | http://purl.uniprot.org/core/title | "Large-Scale Quantitative Proteomics Identifies the Ubiquitin Ligase Nedd4-1 as an Essential Regulator of Liver Regeneration."xsd:string |
| http://purl.uniprot.org/citations/28890072 | http://purl.uniprot.org/core/volume | "42"xsd:string |