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| http://purl.uniprot.org/citations/28890336 | http://www.w3.org/2000/01/rdf-schema#comment | "The Hsp90 system in the eukaryotic cytosol is characterized by a cohort of co-chaperones that bind to Hsp90 and affect its function. Although progress has been made regarding the underlying biochemical mechanisms, how co-chaperones influence Hsp90 client proteins in vivo has remained elusive. By investigating the effect of 12 Hsp90 co-chaperones on the activity of different client proteins in yeast, we find that deletion of co-chaperones can have a neutral or negative effect on client activity but can also lead to more active clients. Only a few co-chaperones are active on all clients studied. Closely related clients and even point mutants can depend on different co-chaperones. These effects are direct because differences in client-co-chaperone interactions can be reconstituted in vitro. Interestingly, some co-chaperones affect client conformation in vivo. Thus, co-chaperones adapt the Hsp90 cycle to the requirements of the client proteins, ensuring optimal activation."xsd:string |
| http://purl.uniprot.org/citations/28890336 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2017.08.004"xsd:string |
| http://purl.uniprot.org/citations/28890336 | http://purl.uniprot.org/core/author | "Buchner J."xsd:string |
| http://purl.uniprot.org/citations/28890336 | http://purl.uniprot.org/core/author | "Rutz D.A."xsd:string |
| http://purl.uniprot.org/citations/28890336 | http://purl.uniprot.org/core/author | "Sahasrabudhe P."xsd:string |
| http://purl.uniprot.org/citations/28890336 | http://purl.uniprot.org/core/author | "Rohrberg J."xsd:string |
| http://purl.uniprot.org/citations/28890336 | http://purl.uniprot.org/core/author | "Biebl M.M."xsd:string |
| http://purl.uniprot.org/citations/28890336 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28890336 | http://purl.uniprot.org/core/name | "Mol Cell"xsd:string |
| http://purl.uniprot.org/citations/28890336 | http://purl.uniprot.org/core/pages | "947-961.e5"xsd:string |
| http://purl.uniprot.org/citations/28890336 | http://purl.uniprot.org/core/title | "The Plasticity of the Hsp90 Co-chaperone System."xsd:string |
| http://purl.uniprot.org/citations/28890336 | http://purl.uniprot.org/core/volume | "67"xsd:string |
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