| http://purl.uniprot.org/citations/28890337 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28890337 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28890337 | http://www.w3.org/2000/01/rdf-schema#comment | "Late in their maturation, nascent small (40S) ribosomal subunits bind 60S subunits to produce 80S-like ribosomes. Because of the analogy of this translation-like cycle to actual translation, and because 80S-like ribosomes do not produce any protein, it has been suggested that this represents a quality control mechanism for subunit functionality. Here we use genetic and biochemical experiments to show that the essential ATPase Fap7 promotes formation of the rotated state, a key intermediate in translocation, thereby releasing the essential assembly factor Dim1 from pre-40S subunits. Bypassing this quality control step produces defects in reading frame maintenance. These results show how progress in the maturation cascade is linked to a test for a key functionality of 40S ribosomes: their ability to translocate the mRNA⋅tRNA pair. Furthermore, our data demonstrate for the first time that the translation-like cycle is a quality control mechanism that ensures the fidelity of the cellular ribosome pool."xsd:string |
| http://purl.uniprot.org/citations/28890337 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2017.08.007"xsd:string |
| http://purl.uniprot.org/citations/28890337 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2017.08.007"xsd:string |
| http://purl.uniprot.org/citations/28890337 | http://purl.uniprot.org/core/author | "Bhaskaran H."xsd:string |
| http://purl.uniprot.org/citations/28890337 | http://purl.uniprot.org/core/author | "Bhaskaran H."xsd:string |
| http://purl.uniprot.org/citations/28890337 | http://purl.uniprot.org/core/author | "Strunk B.S."xsd:string |
| http://purl.uniprot.org/citations/28890337 | http://purl.uniprot.org/core/author | "Strunk B.S."xsd:string |
| http://purl.uniprot.org/citations/28890337 | http://purl.uniprot.org/core/author | "Collins J.C."xsd:string |
| http://purl.uniprot.org/citations/28890337 | http://purl.uniprot.org/core/author | "Collins J.C."xsd:string |
| http://purl.uniprot.org/citations/28890337 | http://purl.uniprot.org/core/author | "Ghalei H."xsd:string |
| http://purl.uniprot.org/citations/28890337 | http://purl.uniprot.org/core/author | "Ghalei H."xsd:string |
| http://purl.uniprot.org/citations/28890337 | http://purl.uniprot.org/core/author | "Karbstein K."xsd:string |
| http://purl.uniprot.org/citations/28890337 | http://purl.uniprot.org/core/author | "Karbstein K."xsd:string |
| http://purl.uniprot.org/citations/28890337 | http://purl.uniprot.org/core/author | "Trepreau J."xsd:string |
| http://purl.uniprot.org/citations/28890337 | http://purl.uniprot.org/core/author | "Trepreau J."xsd:string |
| http://purl.uniprot.org/citations/28890337 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28890337 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28890337 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |
| http://purl.uniprot.org/citations/28890337 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |
| http://purl.uniprot.org/citations/28890337 | http://purl.uniprot.org/core/pages | "990-1000.e3"xsd:string |
| http://purl.uniprot.org/citations/28890337 | http://purl.uniprot.org/core/pages | "990-1000.e3"xsd:string |
| http://purl.uniprot.org/citations/28890337 | http://purl.uniprot.org/core/title | "The ATPase Fap7 tests the ability to carry out translocation-like conformational changes and releases dim1 during 40S ribosome maturation."xsd:string |
| http://purl.uniprot.org/citations/28890337 | http://purl.uniprot.org/core/title | "The ATPase Fap7 tests the ability to carry out translocation-like conformational changes and releases dim1 during 40S ribosome maturation."xsd:string |