| http://purl.uniprot.org/citations/28894005 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28894005 | http://www.w3.org/2000/01/rdf-schema#comment | "The transmembrane semaphorin Sema-1a acts as both a ligand and a receptor to regulate axon-axon repulsion during neural development. Pebble (Pbl), a Rho guanine nucleotide exchange factor, mediates Sema-1a reverse signaling through association with the N-terminal region of the Sema-1a intracellular domain (ICD), resulting in cytoskeletal reorganization. Here, we uncover two additional Sema-1a interacting proteins, varicose (Vari) and cheerio (Cher), each with neuronal functions required for motor axon pathfinding. Vari is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins, members of which can serve as scaffolds to organize signaling complexes. Cher is related to actin filament cross-linking proteins that regulate actin cytoskeleton dynamics. The PDZ domain binding motif found in the most C-terminal region of the Sema-1a ICD is necessary for interaction with Vari, but not Cher, indicative of distinct binding modalities. Pbl/Sema-1a-mediated repulsive guidance is potentiated by both vari and cher Genetic analyses further suggest that scaffolding functions of Vari and Cher play an important role in Pbl-mediated Sema-1a reverse signaling. These results define intracellular components critical for signal transduction from the Sema-1a receptor to the cytoskeleton and provide insight into mechanisms underlying semaphorin-induced localized changes in cytoskeletal organization."xsd:string |
| http://purl.uniprot.org/citations/28894005 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1713010114"xsd:string |
| http://purl.uniprot.org/citations/28894005 | http://purl.uniprot.org/core/author | "Hong Y.G."xsd:string |
| http://purl.uniprot.org/citations/28894005 | http://purl.uniprot.org/core/author | "Brown M.P."xsd:string |
| http://purl.uniprot.org/citations/28894005 | http://purl.uniprot.org/core/author | "Yang D.S."xsd:string |
| http://purl.uniprot.org/citations/28894005 | http://purl.uniprot.org/core/author | "Jeong S."xsd:string |
| http://purl.uniprot.org/citations/28894005 | http://purl.uniprot.org/core/author | "Kolodkin A.L."xsd:string |
| http://purl.uniprot.org/citations/28894005 | http://purl.uniprot.org/core/author | "Mitchell S.P."xsd:string |
| http://purl.uniprot.org/citations/28894005 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28894005 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/28894005 | http://purl.uniprot.org/core/pages | "E8254-E8263"xsd:string |
| http://purl.uniprot.org/citations/28894005 | http://purl.uniprot.org/core/title | "Varicose and cheerio collaborate with pebble to mediate semaphorin-1a reverse signaling in Drosophila."xsd:string |
| http://purl.uniprot.org/citations/28894005 | http://purl.uniprot.org/core/volume | "114"xsd:string |
| http://purl.uniprot.org/citations/28894005 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28894005 |
| http://purl.uniprot.org/citations/28894005 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28894005 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KHN1-mappedCitation-28894005 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28894005 |
| http://purl.uniprot.org/uniprot/#_D2NUE8-mappedCitation-28894005 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28894005 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KGT8-mappedCitation-28894005 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28894005 |
| http://purl.uniprot.org/uniprot/#_A0A0B4JCY6-mappedCitation-28894005 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28894005 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KG47-mappedCitation-28894005 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28894005 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KGB3-mappedCitation-28894005 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28894005 |
| http://purl.uniprot.org/uniprot/#_A4V310-mappedCitation-28894005 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28894005 |
| http://purl.uniprot.org/uniprot/#_A1XXK0-mappedCitation-28894005 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28894005 |
| http://purl.uniprot.org/uniprot/#_A1XXK1-mappedCitation-28894005 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28894005 |