| http://purl.uniprot.org/citations/28894236 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28894236 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28894236 | http://www.w3.org/2000/01/rdf-schema#comment | "Autophagy is a conserved cellular recycling and trafficking pathway in eukaryotic cells and has been reported to be important in the virulence of a number of microbial pathogens. Here, we report genome-wide identification and characterization of autophagy-related genes (ATGs) in the wheat pathogenic fungus Fusarium graminearum. We identified twenty-eight genes associated with the regulation and operation of autophagy in F. graminearum. Using targeted gene deletion, we generated a set of 28 isogenic mutants. Autophagy mutants were classified into two groups by differences in their growth patterns. Radial growth of 18 Group 1 ATG mutants was significantly reduced compared to the wild-type strain PH-1, while 10 Group 2 mutants grew normally. Loss of any of the ATG genes, except FgATG17, prevented the fungus from causing Fusarium head blight disease. Moreover, subsets of autophagy genes were necessary for asexual/sexual differentiation and deoxynivalenol (DON) production, respectively. FgATG1 and FgATG5 were investigated in detail and showed severe defects in autophagy. Taken together, we conclude that autophagy plays a critical role in growth, asexual/sexual sporulation, deoxynivalenol production and virulence in F. graminearum."xsd:string |
| http://purl.uniprot.org/citations/28894236 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41598-017-11640-z"xsd:string |
| http://purl.uniprot.org/citations/28894236 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41598-017-11640-z"xsd:string |
| http://purl.uniprot.org/citations/28894236 | http://purl.uniprot.org/core/author | "Wang C."xsd:string |
| http://purl.uniprot.org/citations/28894236 | http://purl.uniprot.org/core/author | "Wang C."xsd:string |
| http://purl.uniprot.org/citations/28894236 | http://purl.uniprot.org/core/author | "Wang Z."xsd:string |
| http://purl.uniprot.org/citations/28894236 | http://purl.uniprot.org/core/author | "Wang Z."xsd:string |
| http://purl.uniprot.org/citations/28894236 | http://purl.uniprot.org/core/author | "Yang N."xsd:string |
| http://purl.uniprot.org/citations/28894236 | http://purl.uniprot.org/core/author | "Yang N."xsd:string |
| http://purl.uniprot.org/citations/28894236 | http://purl.uniprot.org/core/author | "Que Y."xsd:string |
| http://purl.uniprot.org/citations/28894236 | http://purl.uniprot.org/core/author | "Que Y."xsd:string |
| http://purl.uniprot.org/citations/28894236 | http://purl.uniprot.org/core/author | "Talbot N.J."xsd:string |
| http://purl.uniprot.org/citations/28894236 | http://purl.uniprot.org/core/author | "Talbot N.J."xsd:string |
| http://purl.uniprot.org/citations/28894236 | http://purl.uniprot.org/core/author | "Lv W."xsd:string |
| http://purl.uniprot.org/citations/28894236 | http://purl.uniprot.org/core/author | "Lv W."xsd:string |
| http://purl.uniprot.org/citations/28894236 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28894236 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28894236 | http://purl.uniprot.org/core/name | "Sci. Rep."xsd:string |
| http://purl.uniprot.org/citations/28894236 | http://purl.uniprot.org/core/name | "Sci. Rep."xsd:string |
| http://purl.uniprot.org/citations/28894236 | http://purl.uniprot.org/core/pages | "11062"xsd:string |
| http://purl.uniprot.org/citations/28894236 | http://purl.uniprot.org/core/pages | "11062"xsd:string |
| http://purl.uniprot.org/citations/28894236 | http://purl.uniprot.org/core/title | "Genome-wide functional analysis reveals that autophagy is necessary for growth, sporulation, deoxynivalenol production and virulence in Fusarium graminearum."xsd:string |
| http://purl.uniprot.org/citations/28894236 | http://purl.uniprot.org/core/title | "Genome-wide functional analysis reveals that autophagy is necessary for growth, sporulation, deoxynivalenol production and virulence in Fusarium graminearum."xsd:string |