| http://purl.uniprot.org/citations/28906511 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28906511 | http://www.w3.org/2000/01/rdf-schema#comment | "PurposeTo investigate whether polymorphisms of cluster of differentiation 14 (CD14), tumor necrosis factor alpha (TNFα), interleukin (IL)6, IL10, and IL1ra genes are associated with the risk of peri-implantitis susceptibility in patients with dental implants in the Serbian population.Materials and methodsIsolated DNA from the blood was used for IL10-1082, TNFα-308, IL6-174, CD14-159, and interleukin 1 receptor antagonist (IL1ra) genotyping using polymerase chain reaction (PCR)-based methodology. Clinical parameters included: peri-implant pocket depth (PPD), Plaque Index (PI), Gingival Index (GI), bleeding on probing (BOP), and radiologic bone loss.ResultsThe study included 98 patients with dental implants in function for at least 1 year, divided into peri-implantitis (34) and healthy peri-implant tissue (64) groups. The percentage distribution of smokers was significantly different between patients who developed peri-implantitis and patients with healthy peri-implant tissue (71% vs 42%, respectively) and associated with increased peri-implantitis risk (OR: 3.289, 95% CI: 1.352 to 8.001; P = .007). A positive history of periodontitis was more frequent in the peri-implantitis group (62%) than in the healthy peri-implant tissue (20%) group and associated with increased peri-implantitis risk (OR: 6.337, 95% CI: 2.522 to 15.927; P = .0001). Frequencies of CD14-159, TNFα-308, IL10-1082, and IL6-174 genotypes were significantly different between patients with and without peri-implantitis. However, logistic regression revealed only TNFα-308 polymorphic GA/AA genotypes (OR: 8.890, 95% CI: 2.15 to 36.7; P = .003) and smoking (OR: 6.2, 95% CI: 1.44 to 26.7; P = .014) as independent factors associated with increased peri-implantitis risk, while CD14-159 polymorphic CT/TT genotypes were associated with decreased risk for peri-implantitis (OR: 0.059, 95% CI: 0.009 to 0.355; P = .002).ConclusionThe findings suggest that smoking and the presence of TNFα-308 GA/AA genotypes may increase the risk for peri-implantitis, while CD14-159 polymorphic CT/TT genotypes decrease the risk. The results also indicate significant association of CD14-159, TNFα-308, and IL6-174 genotypes and clinical parameters in the Serbian population. However, future studies in larger patient groups are necessary to confirm these observations."xsd:string |
| http://purl.uniprot.org/citations/28906511 | http://purl.org/dc/terms/identifier | "doi:10.11607/jomi.5814"xsd:string |
| http://purl.uniprot.org/citations/28906511 | http://purl.uniprot.org/core/author | "Magic Z."xsd:string |
| http://purl.uniprot.org/citations/28906511 | http://purl.uniprot.org/core/author | "Zeljic K."xsd:string |
| http://purl.uniprot.org/citations/28906511 | http://purl.uniprot.org/core/author | "Cikota-Aleksic B."xsd:string |
| http://purl.uniprot.org/citations/28906511 | http://purl.uniprot.org/core/author | "Petkovic-Curcin A."xsd:string |
| http://purl.uniprot.org/citations/28906511 | http://purl.uniprot.org/core/author | "Dakovic D."xsd:string |
| http://purl.uniprot.org/citations/28906511 | http://purl.uniprot.org/core/author | "Tatic Z."xsd:string |
| http://purl.uniprot.org/citations/28906511 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28906511 | http://purl.uniprot.org/core/name | "Int J Oral Maxillofac Implants"xsd:string |
| http://purl.uniprot.org/citations/28906511 | http://purl.uniprot.org/core/pages | "e241-e248"xsd:string |
| http://purl.uniprot.org/citations/28906511 | http://purl.uniprot.org/core/title | "Association of Cytokine Gene Polymorphism with Peri-implantitis Risk."xsd:string |
| http://purl.uniprot.org/citations/28906511 | http://purl.uniprot.org/core/volume | "32"xsd:string |
| http://purl.uniprot.org/citations/28906511 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28906511 |
| http://purl.uniprot.org/citations/28906511 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28906511 |
| http://purl.uniprot.org/uniprot/#_A0A0G2YPN5-mappedCitation-28906511 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28906511 |
| http://purl.uniprot.org/uniprot/#_A0A411D318-mappedCitation-28906511 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28906511 |
| http://purl.uniprot.org/uniprot/#_A0A1U9X8M9-mappedCitation-28906511 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28906511 |
| http://purl.uniprot.org/uniprot/#_A0A510GFL8-mappedCitation-28906511 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28906511 |
| http://purl.uniprot.org/uniprot/#_B2R888-mappedCitation-28906511 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28906511 |
| http://purl.uniprot.org/uniprot/#_B5BUQ6-mappedCitation-28906511 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28906511 |
| http://purl.uniprot.org/uniprot/#_A0A977WMN2-mappedCitation-28906511 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28906511 |
| http://purl.uniprot.org/uniprot/#_C1K3N5-mappedCitation-28906511 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28906511 |
| http://purl.uniprot.org/uniprot/#_F1C4A7-mappedCitation-28906511 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28906511 |