| http://purl.uniprot.org/citations/28912134 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28912134 | http://www.w3.org/2000/01/rdf-schema#comment | "Topoisomerase 2 (TOP2) DNA transactions proceed via formation of the TOP2 cleavage complex (TOP2cc), a covalent enzyme-DNA reaction intermediate that is vulnerable to trapping by potent anticancer TOP2 drugs. How genotoxic TOP2 DNA-protein cross-links are resolved is unclear. We found that the SUMO (small ubiquitin-related modifier) ligase ZATT (ZNF451) is a multifunctional DNA repair factor that controls cellular responses to TOP2 damage. ZATT binding to TOP2cc facilitates a proteasome-independent tyrosyl-DNA phosphodiesterase 2 (TDP2) hydrolase activity on stalled TOP2cc. The ZATT SUMO ligase activity further promotes TDP2 interactions with SUMOylated TOP2, regulating efficient TDP2 recruitment through a "split-SIM" SUMO2 engagement platform. These findings uncover a ZATT-TDP2-catalyzed and SUMO2-modulated pathway for direct resolution of TOP2cc."xsd:string |
| http://purl.uniprot.org/citations/28912134 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.aam6468"xsd:string |
| http://purl.uniprot.org/citations/28912134 | http://purl.uniprot.org/core/author | "Williams J.G."xsd:string |
| http://purl.uniprot.org/citations/28912134 | http://purl.uniprot.org/core/author | "Williams R.S."xsd:string |
| http://purl.uniprot.org/citations/28912134 | http://purl.uniprot.org/core/author | "Schellenberg M.J."xsd:string |
| http://purl.uniprot.org/citations/28912134 | http://purl.uniprot.org/core/author | "Cortes-Ledesma F."xsd:string |
| http://purl.uniprot.org/citations/28912134 | http://purl.uniprot.org/core/author | "Mueller G.A."xsd:string |
| http://purl.uniprot.org/citations/28912134 | http://purl.uniprot.org/core/author | "London R.E."xsd:string |
| http://purl.uniprot.org/citations/28912134 | http://purl.uniprot.org/core/author | "Munoz-Cabello A.M."xsd:string |
| http://purl.uniprot.org/citations/28912134 | http://purl.uniprot.org/core/author | "Lieberman J.A."xsd:string |
| http://purl.uniprot.org/citations/28912134 | http://purl.uniprot.org/core/author | "Butler L.R."xsd:string |
| http://purl.uniprot.org/citations/28912134 | http://purl.uniprot.org/core/author | "Herrero-Ruiz A."xsd:string |
| http://purl.uniprot.org/citations/28912134 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28912134 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/28912134 | http://purl.uniprot.org/core/pages | "1412-1416"xsd:string |
| http://purl.uniprot.org/citations/28912134 | http://purl.uniprot.org/core/title | "ZATT (ZNF451)-mediated resolution of topoisomerase 2 DNA-protein cross-links."xsd:string |
| http://purl.uniprot.org/citations/28912134 | http://purl.uniprot.org/core/volume | "357"xsd:string |
| http://purl.uniprot.org/citations/28912134 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28912134 |
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| http://purl.uniprot.org/uniprot/#_P61957-mappedCitation-28912134 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28912134 |