| http://purl.uniprot.org/citations/28912435 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28912435 | http://www.w3.org/2000/01/rdf-schema#comment | "T cells navigate diverse microenvironments to perform immune responses. Micro-scale topographical structures within the tissues, which may inherently exist in normal tissues or may be formed by inflammation or injury, can influence T cell migration, but how T cell migration is affected by such topographical structures have not been investigated. In this study, we fabricated ramp-like structures with a 5 μm height and various slopes, and observed T cells climbing up the ramp-like structures. T cells encountering the ramp-like structures exhibited MLC accumulation near head-tail junctions contacting the ramp-like structures, and made turns to the direction perpendicular to the ramp-like structures. Pharmacological study revealed that lamellipodia formation mediated by arp2/3 and contractility regulated by myosin light chain kinase (MLCK) were responsible for the intriguing turning behavior of T cells climbing the ramp-like structures. Arp2/3 or MLCK inhibition substantially reduced probability of T cells climbing sharp-edged ramp-like structures, indicating intriguing turning behavior of T cells mediated by lamellipodia formation and MLCK activity may be important for T cells to access inflamed or injured tissues with abrupt topographical changes."xsd:string |
| http://purl.uniprot.org/citations/28912435 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41598-017-11938-y"xsd:string |
| http://purl.uniprot.org/citations/28912435 | http://purl.uniprot.org/core/author | "Lee J."xsd:string |
| http://purl.uniprot.org/citations/28912435 | http://purl.uniprot.org/core/author | "Park H."xsd:string |
| http://purl.uniprot.org/citations/28912435 | http://purl.uniprot.org/core/author | "Song K.H."xsd:string |
| http://purl.uniprot.org/citations/28912435 | http://purl.uniprot.org/core/author | "Jung H.R."xsd:string |
| http://purl.uniprot.org/citations/28912435 | http://purl.uniprot.org/core/author | "Doh J."xsd:string |
| http://purl.uniprot.org/citations/28912435 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28912435 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/28912435 | http://purl.uniprot.org/core/pages | "11533"xsd:string |
| http://purl.uniprot.org/citations/28912435 | http://purl.uniprot.org/core/title | "Turning behaviors of T cells climbing up ramp-like structures are regulated by myosin light chain kinase activity and lamellipodia formation."xsd:string |
| http://purl.uniprot.org/citations/28912435 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/28912435 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28912435 |
| http://purl.uniprot.org/citations/28912435 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28912435 |
| http://purl.uniprot.org/uniprot/#_B2RQL6-mappedCitation-28912435 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28912435 |
| http://purl.uniprot.org/uniprot/#_D3Z630-mappedCitation-28912435 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28912435 |
| http://purl.uniprot.org/uniprot/#_Q3UIZ8-mappedCitation-28912435 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28912435 |
| http://purl.uniprot.org/uniprot/D3Z630 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28912435 |
| http://purl.uniprot.org/uniprot/Q3UIZ8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28912435 |
| http://purl.uniprot.org/uniprot/B2RQL6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28912435 |