| http://purl.uniprot.org/citations/28916264 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28916264 | http://www.w3.org/2000/01/rdf-schema#comment | "Double-stranded RNA (dsRNA) is a common by-product of viral infections and acts as a potent trigger of antiviral immunity. In the nematode C. elegans, sid-1 encodes a dsRNA transporter that is highly conserved throughout animal evolution, but the physiological role of SID-1 and its orthologs remains unclear. Here, we show that the mammalian SID-1 ortholog, SIDT2, is required to transport internalized extracellular dsRNA from endocytic compartments into the cytoplasm for immune activation. Sidt2-deficient mice exposed to extracellular dsRNA, encephalomyocarditis virus (EMCV), and herpes simplex virus 1 (HSV-1) show impaired production of antiviral cytokines and-in the case of EMCV and HSV-1-reduced survival. Thus, SIDT2 has retained the dsRNA transport activity of its C. elegans ortholog, and this transport is important for antiviral immunity."xsd:string |
| http://purl.uniprot.org/citations/28916264 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2017.08.007"xsd:string |
| http://purl.uniprot.org/citations/28916264 | http://purl.uniprot.org/core/author | "Baker P.J."xsd:string |
| http://purl.uniprot.org/citations/28916264 | http://purl.uniprot.org/core/author | "Masters S.L."xsd:string |
| http://purl.uniprot.org/citations/28916264 | http://purl.uniprot.org/core/author | "Pang K.C."xsd:string |
| http://purl.uniprot.org/citations/28916264 | http://purl.uniprot.org/core/author | "Garnham A."xsd:string |
| http://purl.uniprot.org/citations/28916264 | http://purl.uniprot.org/core/author | "Smyth G.K."xsd:string |
| http://purl.uniprot.org/citations/28916264 | http://purl.uniprot.org/core/author | "Lundie R.J."xsd:string |
| http://purl.uniprot.org/citations/28916264 | http://purl.uniprot.org/core/author | "Nguyen T.A."xsd:string |
| http://purl.uniprot.org/citations/28916264 | http://purl.uniprot.org/core/author | "Pellegrini M."xsd:string |
| http://purl.uniprot.org/citations/28916264 | http://purl.uniprot.org/core/author | "Hunter C.P."xsd:string |
| http://purl.uniprot.org/citations/28916264 | http://purl.uniprot.org/core/author | "Whitehead L."xsd:string |
| http://purl.uniprot.org/citations/28916264 | http://purl.uniprot.org/core/author | "O'Keeffe M."xsd:string |
| http://purl.uniprot.org/citations/28916264 | http://purl.uniprot.org/core/author | "Tate M.D."xsd:string |
| http://purl.uniprot.org/citations/28916264 | http://purl.uniprot.org/core/author | "Weisman A.S."xsd:string |
| http://purl.uniprot.org/citations/28916264 | http://purl.uniprot.org/core/author | "Elgass K.D."xsd:string |
| http://purl.uniprot.org/citations/28916264 | http://purl.uniprot.org/core/author | "Wicks I.P."xsd:string |
| http://purl.uniprot.org/citations/28916264 | http://purl.uniprot.org/core/author | "Belz G.T."xsd:string |
| http://purl.uniprot.org/citations/28916264 | http://purl.uniprot.org/core/author | "Preston S.P."xsd:string |
| http://purl.uniprot.org/citations/28916264 | http://purl.uniprot.org/core/author | "Barrios M.H."xsd:string |
| http://purl.uniprot.org/citations/28916264 | http://purl.uniprot.org/core/author | "Smith B.R.C."xsd:string |
| http://purl.uniprot.org/citations/28916264 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28916264 | http://purl.uniprot.org/core/name | "Immunity"xsd:string |
| http://purl.uniprot.org/citations/28916264 | http://purl.uniprot.org/core/pages | "498-509.e6"xsd:string |