| http://purl.uniprot.org/citations/28923932 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28923932 | http://www.w3.org/2000/01/rdf-schema#comment | "MicroRNAs (miRNAs) have been known to affect various biological processes by repressing expression of specific genes. Here we describe an essential function of the miR-34/449 family during differentiation of epithelial cells. We found that miR-34/449 suppresses the cell-cycle machinery in vivo and promotes cell-cycle exit, thereby allowing epithelial cell differentiation. Constitutive ablation of all six members of this miRNA family causes derepression of multiple cell cycle-promoting proteins, thereby preventing epithelial cells from exiting the cell cycle and entering a quiescent state. As a result, formation of motile multicilia is strongly inhibited in several tissues such as the respiratory epithelium and the fallopian tube. Consequently, mice lacking miR-34/449 display infertility as well as severe chronic airway disease leading to postnatal death. These results demonstrate that miRNA-mediated repression of the cell cycle is required to allow epithelial cell differentiation."xsd:string |
| http://purl.uniprot.org/citations/28923932 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1702914114"xsd:string |
| http://purl.uniprot.org/citations/28923932 | http://purl.uniprot.org/core/author | "Bronson R.T."xsd:string |
| http://purl.uniprot.org/citations/28923932 | http://purl.uniprot.org/core/author | "Fassl A."xsd:string |
| http://purl.uniprot.org/citations/28923932 | http://purl.uniprot.org/core/author | "Sicinski P."xsd:string |
| http://purl.uniprot.org/citations/28923932 | http://purl.uniprot.org/core/author | "Bowden M."xsd:string |
| http://purl.uniprot.org/citations/28923932 | http://purl.uniprot.org/core/author | "Otto T."xsd:string |
| http://purl.uniprot.org/citations/28923932 | http://purl.uniprot.org/core/author | "Sicinska E."xsd:string |
| http://purl.uniprot.org/citations/28923932 | http://purl.uniprot.org/core/author | "Han R.C."xsd:string |
| http://purl.uniprot.org/citations/28923932 | http://purl.uniprot.org/core/author | "Jecrois E.S."xsd:string |
| http://purl.uniprot.org/citations/28923932 | http://purl.uniprot.org/core/author | "Candido S.V."xsd:string |
| http://purl.uniprot.org/citations/28923932 | http://purl.uniprot.org/core/author | "Lachowicz I.A."xsd:string |
| http://purl.uniprot.org/citations/28923932 | http://purl.uniprot.org/core/author | "Mulry K."xsd:string |
| http://purl.uniprot.org/citations/28923932 | http://purl.uniprot.org/core/author | "Pilarz M.S."xsd:string |
| http://purl.uniprot.org/citations/28923932 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28923932 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/28923932 | http://purl.uniprot.org/core/pages | "10660-10665"xsd:string |
| http://purl.uniprot.org/citations/28923932 | http://purl.uniprot.org/core/title | "Cell cycle-targeting microRNAs promote differentiation by enforcing cell-cycle exit."xsd:string |
| http://purl.uniprot.org/citations/28923932 | http://purl.uniprot.org/core/volume | "114"xsd:string |
| http://purl.uniprot.org/citations/28923932 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28923932 |
| http://purl.uniprot.org/citations/28923932 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28923932 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGA8-mappedCitation-28923932 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28923932 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGH2-mappedCitation-28923932 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28923932 |
| http://purl.uniprot.org/uniprot/#_E9Q9E4-mappedCitation-28923932 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28923932 |