| http://purl.uniprot.org/citations/28924206 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28924206 | http://www.w3.org/2000/01/rdf-schema#comment | "The development of the neocortex requires co-ordination between proliferation and differentiation, as well as the precise orchestration of neuronal migration. Eph/ephrin signaling is crucial in guiding neurons and their projections during embryonic development. In adult ephrin-A2 knockout mice we consistently observed focal patches of disorganized neocortical laminar architecture, ranging in severity from reduced neuronal density to a complete lack of neurons. Loss of ephrin-A2 in the pre-optic area of the diencephalon reduced the migration of neocortex-bound interneurons from this region. Furthermore, ephrin-A2 participates in the creation of excitatory neurons by inhibiting apical progenitor proliferation in the ventricular zone, with the disruption of ephrin-A2 signaling in these cells recapitulating the abnormal neocortex observed in the knockout. The disturbance to the architecture of the neocortex observed following deletion of ephrin-A2 signaling shares many similarities with defects found in the neocortex of children diagnosed with autism spectrum disorder."xsd:string |
| http://purl.uniprot.org/citations/28924206 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41598-017-12185-x"xsd:string |
| http://purl.uniprot.org/citations/28924206 | http://purl.uniprot.org/core/author | "Rodger J."xsd:string |
| http://purl.uniprot.org/citations/28924206 | http://purl.uniprot.org/core/author | "Bourne J.A."xsd:string |
| http://purl.uniprot.org/citations/28924206 | http://purl.uniprot.org/core/author | "Homman-Ludiye J."xsd:string |
| http://purl.uniprot.org/citations/28924206 | http://purl.uniprot.org/core/author | "Kwan W.C."xsd:string |
| http://purl.uniprot.org/citations/28924206 | http://purl.uniprot.org/core/author | "de Souza M.J."xsd:string |
| http://purl.uniprot.org/citations/28924206 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28924206 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/28924206 | http://purl.uniprot.org/core/pages | "11813"xsd:string |
| http://purl.uniprot.org/citations/28924206 | http://purl.uniprot.org/core/title | "Ephrin-A2 regulates excitatory neuron differentiation and interneuron migration in the developing neocortex."xsd:string |
| http://purl.uniprot.org/citations/28924206 | http://purl.uniprot.org/core/volume | "7"xsd:string |
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