| http://purl.uniprot.org/citations/28927446 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28927446 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundObsessive-compulsive disorder (OCD) is a severe neuropsychiatric condition affecting 1-3% of the worldwide population. OCD has a strong genetic component, and the SLC1A1 gene that encodes neuronal glutamate transporter EAAT3 is a strong candidate for this disorder. To evaluate the impact of reduced EAAT3 expression in vivo, we studied male EAAT3 heterozygous and wild-type littermate mice using a battery of behavioral paradigms relevant to anxiety (open field test, elevated plus maze) and compulsivity (marble burying), as well as locomotor activity induced by amphetamine. Using high-performance liquid chromatography, we also determined tissue neurotransmitter levels in cortex, striatum and thalamus-brain areas that are relevant to OCD.ResultsCompared to wild-type littermates, EAAT3 heterozygous male mice have unaltered baseline anxiety-like, compulsive-like behavior and locomotor activity. Administration of acute amphetamine (5 mg/kg intraperitoneally) increased locomotion with no differences across genotypes. Tissue levels of glutamate, GABA, dopamine and serotonin did not vary between EAAT3 heterozygous and wild-type mice.ConclusionsOur results indicate that reduced EAAT3 expression does not impact neurotransmitter content in the corticostriatal circuit nor alter anxiety or compulsive-like behaviors."xsd:string |
| http://purl.uniprot.org/citations/28927446 | http://purl.org/dc/terms/identifier | "doi:10.1186/s40659-017-0138-3"xsd:string |
| http://purl.uniprot.org/citations/28927446 | http://purl.uniprot.org/core/author | "Murphy D.L."xsd:string |
| http://purl.uniprot.org/citations/28927446 | http://purl.uniprot.org/core/author | "Arriagada G."xsd:string |
| http://purl.uniprot.org/citations/28927446 | http://purl.uniprot.org/core/author | "Gonzalez L.F."xsd:string |
| http://purl.uniprot.org/citations/28927446 | http://purl.uniprot.org/core/author | "Moya P.R."xsd:string |
| http://purl.uniprot.org/citations/28927446 | http://purl.uniprot.org/core/author | "Sotomayor-Zarate R."xsd:string |
| http://purl.uniprot.org/citations/28927446 | http://purl.uniprot.org/core/author | "Cisternas-Olmedo M."xsd:string |
| http://purl.uniprot.org/citations/28927446 | http://purl.uniprot.org/core/author | "Delgado-Acevedo C."xsd:string |
| http://purl.uniprot.org/citations/28927446 | http://purl.uniprot.org/core/author | "Henriquez-Belmar F."xsd:string |
| http://purl.uniprot.org/citations/28927446 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28927446 | http://purl.uniprot.org/core/name | "Biol Res"xsd:string |
| http://purl.uniprot.org/citations/28927446 | http://purl.uniprot.org/core/pages | "29"xsd:string |
| http://purl.uniprot.org/citations/28927446 | http://purl.uniprot.org/core/title | "Neurochemical and behavioral characterization of neuronal glutamate transporter EAAT3 heterozygous mice."xsd:string |
| http://purl.uniprot.org/citations/28927446 | http://purl.uniprot.org/core/volume | "50"xsd:string |
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