| http://purl.uniprot.org/citations/28931602 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28931602 | http://www.w3.org/2000/01/rdf-schema#comment | "The role of the nucleotide-binding domain and leucine-rich repeat containing receptor NLRP10 in disease is incompletely understood. Using three mouse strains lacking the gene encoding NLRP10, only one of which had a coincidental mutation in DOCK8, we documented a role for NLRP10 as a suppressor of the cutaneous inflammatory response to Leishmania major infection. There was no evidence that the enhanced local inflammation was due to enhanced inflammasome activity. NLRP10/DOCK8-deficient mice harbored lower parasite burdens at the cutaneous site of inoculation compared with wild-type controls, whereas NLRP10-deficient mice and controls had similar parasite loads, suggesting that DOCK8 promotes local growth of parasites in the skin, whereas NLRP10 does not. NLRP10-deficient mice developed vigorous adaptive immune responses, indicating that there was not a global defect in the development of Ag-specific cytokine production. Bone marrow chimeras showed that the anti-inflammatory role of NLRP10 was mediated by NLRP10 expressed in resident cells in the skin rather than by bone marrow-derived cells. These data suggest a novel role for NLRP10 in the resolution of local inflammatory responses during L. major infection."xsd:string |
| http://purl.uniprot.org/citations/28931602 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1500832"xsd:string |
| http://purl.uniprot.org/citations/28931602 | http://purl.uniprot.org/core/author | "Chen Y."xsd:string |
| http://purl.uniprot.org/citations/28931602 | http://purl.uniprot.org/core/author | "Wilson M.E."xsd:string |
| http://purl.uniprot.org/citations/28931602 | http://purl.uniprot.org/core/author | "Davis R.E."xsd:string |
| http://purl.uniprot.org/citations/28931602 | http://purl.uniprot.org/core/author | "Graff J.W."xsd:string |
| http://purl.uniprot.org/citations/28931602 | http://purl.uniprot.org/core/author | "Sutterwala F.S."xsd:string |
| http://purl.uniprot.org/citations/28931602 | http://purl.uniprot.org/core/author | "Ulland T.K."xsd:string |
| http://purl.uniprot.org/citations/28931602 | http://purl.uniprot.org/core/author | "Clay G.M."xsd:string |
| http://purl.uniprot.org/citations/28931602 | http://purl.uniprot.org/core/author | "Scorza B.M."xsd:string |
| http://purl.uniprot.org/citations/28931602 | http://purl.uniprot.org/core/author | "Valadares D.G."xsd:string |
| http://purl.uniprot.org/citations/28931602 | http://purl.uniprot.org/core/author | "Zhanbolat B.S."xsd:string |
| http://purl.uniprot.org/citations/28931602 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28931602 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/28931602 | http://purl.uniprot.org/core/pages | "2823-2833"xsd:string |
| http://purl.uniprot.org/citations/28931602 | http://purl.uniprot.org/core/title | "An Anti-Inflammatory Role for NLRP10 in Murine Cutaneous Leishmaniasis."xsd:string |
| http://purl.uniprot.org/citations/28931602 | http://purl.uniprot.org/core/volume | "199"xsd:string |
| http://purl.uniprot.org/citations/28931602 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28931602 |
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| http://purl.uniprot.org/uniprot/#_A0A0U1RQ20-mappedCitation-28931602 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28931602 |
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| http://purl.uniprot.org/uniprot/#_B9EJ70-mappedCitation-28931602 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28931602 |
| http://purl.uniprot.org/uniprot/#_Q14BA2-mappedCitation-28931602 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28931602 |