| http://purl.uniprot.org/citations/28931725 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28931725 | http://www.w3.org/2000/01/rdf-schema#comment | "The crucial interplay between metabolic remodeling and the epigenetics could contribute to promote cancer progression. A remarkable association within interaction, LKB1 has been reported, suggesting that the expression of key enzymes involving de novo serine synthesis and DNA methyltransferases like DNMT1 and DNMT3A increase LKB1-deficiency cells. However, the complex interactional link between metabolic remodeling and the epigenetics is still unclear. Hence, we focus on the relationship between YAP/TAZ and serine metabolism to control methylation of DNA or histone in breast cancer with LKB1 deficiency. We hypothesize that YAP/TAZ may have the function to activate key enzymes involving serine metabolism like PSPH and up-regulate the amino acid transporters to supply sources of serine synthesis through activation of C-MYC with TEAD1. Further, we speculate that YAP/TAZ in dependent of FOS may promote DNMT1 and subsequently mediate DNMT1-G9A complex involving serine metabolism and the methylation of DNA and histone. We hope that our study will stimulate further studies and a new targeted therapy and early medical intervention for YAP/TAZ could be a useful option for breast cancer cases complicated with LKB1 deficiency."xsd:string |
| http://purl.uniprot.org/citations/28931725 | http://purl.org/dc/terms/identifier | "doi:10.1042/bsr20171072"xsd:string |
| http://purl.uniprot.org/citations/28931725 | http://purl.uniprot.org/core/author | "Chen X."xsd:string |
| http://purl.uniprot.org/citations/28931725 | http://purl.uniprot.org/core/author | "Li J."xsd:string |
| http://purl.uniprot.org/citations/28931725 | http://purl.uniprot.org/core/author | "Li B."xsd:string |
| http://purl.uniprot.org/citations/28931725 | http://purl.uniprot.org/core/author | "Zhang H."xsd:string |
| http://purl.uniprot.org/citations/28931725 | http://purl.uniprot.org/core/author | "Wu Q."xsd:string |
| http://purl.uniprot.org/citations/28931725 | http://purl.uniprot.org/core/author | "Sun S."xsd:string |
| http://purl.uniprot.org/citations/28931725 | http://purl.uniprot.org/core/author | "Sun S.'"xsd:string |
| http://purl.uniprot.org/citations/28931725 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28931725 | http://purl.uniprot.org/core/name | "Biosci Rep"xsd:string |
| http://purl.uniprot.org/citations/28931725 | http://purl.uniprot.org/core/pages | "BSR20171072"xsd:string |
| http://purl.uniprot.org/citations/28931725 | http://purl.uniprot.org/core/title | "YAP/TAZ-mediated activation of serine metabolism and methylation regulation is critical for LKB1-deficient breast cancer progression."xsd:string |
| http://purl.uniprot.org/citations/28931725 | http://purl.uniprot.org/core/volume | "37"xsd:string |
| http://purl.uniprot.org/citations/28931725 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28931725 |
| http://purl.uniprot.org/citations/28931725 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28931725 |
| http://purl.uniprot.org/uniprot/#_D4P556-mappedCitation-28931725 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28931725 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z4C7-mappedCitation-28931725 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28931725 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z4D1-mappedCitation-28931725 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28931725 |
| http://purl.uniprot.org/uniprot/#_A6YR18-mappedCitation-28931725 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28931725 |
| http://purl.uniprot.org/uniprot/#_B4E2Y3-mappedCitation-28931725 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28931725 |
| http://purl.uniprot.org/uniprot/#_P46937-mappedCitation-28931725 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28931725 |
| http://purl.uniprot.org/uniprot/#_Q15831-mappedCitation-28931725 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28931725 |
| http://purl.uniprot.org/uniprot/#_K0KVU2-mappedCitation-28931725 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28931725 |