| http://purl.uniprot.org/citations/28931751 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28931751 | http://www.w3.org/2000/01/rdf-schema#comment | "Supplementing diets with high potassium helps reduce hypertension in humans. Inwardly rectifying K+ channels Kir4.1 (Kcnj10) and Kir5.1 (Kcnj16) are highly expressed in the basolateral membrane of distal renal tubules and contribute to Na+ reabsorption and K+ secretion through the direct control of transepithelial voltage. To define the importance of Kir5.1 in blood pressure control under conditions of salt-induced hypertension, we generated a Kcnj16 knockout in Dahl salt-sensitive (SS) rats (SSKcnj16-/-). SSKcnj16-/-rats exhibited hypokalemia and reduced blood pressure, and when fed a high-salt diet (4% NaCl), experienced 100% mortality within a few days triggered by salt wasting and severe hypokalemia. Electrophysiological recordings of basolateral K+ channels in the collecting ducts isolated from SSKcnj16-/-rats revealed activity of only homomeric Kir4.1 channels. Kir4.1 expression was upregulated in SSKcnj16-/-rats, but the protein was predominantly localized in the cytosol in SSKcnj16-/-rats. Benzamil, but not hydrochlorothiazide or furosemide, rescued this phenotype from mortality on a high-salt diet. Supplementation of high-salt diet with increased potassium (2% KCl) prevented mortality in SSKcnj16-/-rats and prevented or mitigated hypertension in SSKcnj16-/- or control SS rats, respectively. Our results demonstrate that Kir5.1 channels are key regulators of renal salt handling in SS hypertension."xsd:string |
| http://purl.uniprot.org/citations/28931751 | http://purl.org/dc/terms/identifier | "doi:10.1172/jci.insight.92331"xsd:string |
| http://purl.uniprot.org/citations/28931751 | http://purl.uniprot.org/core/author | "Jacob H.J."xsd:string |
| http://purl.uniprot.org/citations/28931751 | http://purl.uniprot.org/core/author | "Geurts A.M."xsd:string |
| http://purl.uniprot.org/citations/28931751 | http://purl.uniprot.org/core/author | "Palygin O."xsd:string |
| http://purl.uniprot.org/citations/28931751 | http://purl.uniprot.org/core/author | "Staruschenko A."xsd:string |
| http://purl.uniprot.org/citations/28931751 | http://purl.uniprot.org/core/author | "Ilatovskaya D.V."xsd:string |
| http://purl.uniprot.org/citations/28931751 | http://purl.uniprot.org/core/author | "Levchenko V."xsd:string |
| http://purl.uniprot.org/citations/28931751 | http://purl.uniprot.org/core/author | "Hodges M.R."xsd:string |
| http://purl.uniprot.org/citations/28931751 | http://purl.uniprot.org/core/author | "Pavlov T.S."xsd:string |
| http://purl.uniprot.org/citations/28931751 | http://purl.uniprot.org/core/author | "Pochynyuk O.M."xsd:string |
| http://purl.uniprot.org/citations/28931751 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28931751 | http://purl.uniprot.org/core/name | "JCI Insight"xsd:string |
| http://purl.uniprot.org/citations/28931751 | http://purl.uniprot.org/core/pages | "92331"xsd:string |
| http://purl.uniprot.org/citations/28931751 | http://purl.uniprot.org/core/title | "Essential role of Kir5.1 channels in renal salt handling and blood pressure control."xsd:string |
| http://purl.uniprot.org/citations/28931751 | http://purl.uniprot.org/core/volume | "2"xsd:string |
| http://purl.uniprot.org/citations/28931751 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28931751 |
| http://purl.uniprot.org/citations/28931751 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28931751 |
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| http://purl.uniprot.org/uniprot/#_P52191-mappedCitation-28931751 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28931751 |
| http://purl.uniprot.org/uniprot/#_Q68G21-mappedCitation-28931751 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28931751 |
| http://purl.uniprot.org/uniprot/P52191 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28931751 |
| http://purl.uniprot.org/uniprot/Q68G21 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28931751 |