| http://purl.uniprot.org/citations/28931918 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28931918 | http://www.w3.org/2000/01/rdf-schema#comment | "Antithyroid drug (ATD)-induced agranulocytosis is associated with human leukocyte antigen (HLA) and nearby genes in Southeast Asian and European populations. The susceptibility of the Han population from northern China to ATD-induced agranulocytosis has not been reported. We evaluated the associations of genetic variants at the HLA-B and HLA-DRB1 loci and 32 candidate single nucleotide polymorphisms (SNPs) with agranulocytosis in 29 patients with ATD-induced agranulocytosis and in 140 patients with Graves' disease (GD) as controls. All subjects were of Han descent from northern China. HLA-B*27:05 (P = 1.10 × 10-4), HLA-B*38:02 (P = 2.41 × 10-4) and HLA-DRB1*08:03 (P = 1.57 × 10-3) were susceptibility HLA variants for ATD-induced agranulocytosis. All subjects carrying the HLA-B*27:05 allele had agranulocytosis. The odds ratios (ORs) comparing allele carriers to non-carriers were 66.24 (95% confidence interval (CI): 3.54-1239.66) for HLA-B*27:05, 7.525 (95% CI: 2.294-24.68) for HLA-B*38:02 and 4.316 (95% CI: 1.56-11.93) for HLA-DRB1*08:03. Two SNPs, rs2596487 (OR = 4.196, 95% CI = 2.086-8.441, P = 2.08 × 10-5) and rs2228391 (OR = 3.621, 95% CI = 1.596-8.217, P = 1.2 × 10-3), were independently associated with ATD-induced agranulocytosis. Subjects carrying the 'A' allele of rs1811197 or HLA-B*38:02 showed lower minimum granulocyte counts than non-carriers (P = 4.74 × 10-4 and P = 7.39 × 10-4, respectively). Our findings support the association between genetic variations of HLA-B and HLA-DRB1 with ATD-induced agranulocytosis in a Han population from northern China."xsd:string |
| http://purl.uniprot.org/citations/28931918 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41598-017-12350-2"xsd:string |
| http://purl.uniprot.org/citations/28931918 | http://purl.uniprot.org/core/author | "Chen P."xsd:string |
| http://purl.uniprot.org/citations/28931918 | http://purl.uniprot.org/core/author | "He Y."xsd:string |
| http://purl.uniprot.org/citations/28931918 | http://purl.uniprot.org/core/author | "Li W."xsd:string |
| http://purl.uniprot.org/citations/28931918 | http://purl.uniprot.org/core/author | "Liu S."xsd:string |
| http://purl.uniprot.org/citations/28931918 | http://purl.uniprot.org/core/author | "Yang J."xsd:string |
| http://purl.uniprot.org/citations/28931918 | http://purl.uniprot.org/core/author | "Zhang Q."xsd:string |
| http://purl.uniprot.org/citations/28931918 | http://purl.uniprot.org/core/author | "Zheng J."xsd:string |
| http://purl.uniprot.org/citations/28931918 | http://purl.uniprot.org/core/author | "Zhang B."xsd:string |
| http://purl.uniprot.org/citations/28931918 | http://purl.uniprot.org/core/author | "Zhu F."xsd:string |
| http://purl.uniprot.org/citations/28931918 | http://purl.uniprot.org/core/author | "Hou P."xsd:string |
| http://purl.uniprot.org/citations/28931918 | http://purl.uniprot.org/core/author | "Shi B."xsd:string |
| http://purl.uniprot.org/citations/28931918 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28931918 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/28931918 | http://purl.uniprot.org/core/pages | "11950"xsd:string |
| http://purl.uniprot.org/citations/28931918 | http://purl.uniprot.org/core/title | "Association of HLA-B and HLA-DRB1 polymorphisms with antithyroid drug-induced agranulocytosis in a Han population from northern China."xsd:string |
| http://purl.uniprot.org/citations/28931918 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/28931918 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28931918 |
| http://purl.uniprot.org/citations/28931918 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28931918 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3H3-mappedCitation-28931918 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28931918 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3I1-mappedCitation-28931918 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28931918 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C552-mappedCitation-28931918 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28931918 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DC98-mappedCitation-28931918 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28931918 |