| http://purl.uniprot.org/citations/28943241 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28943241 | http://www.w3.org/2000/01/rdf-schema#comment | "YAP/TAZ are the major mediators of mammalian Hippo signaling; however, their precise function in the gastrointestinal tract remains poorly understood. Here we dissect the distinct roles of YAP/TAZ in endodermal epithelium and mesenchyme and find that, although dispensable for gastrointestinal epithelial development and homeostasis, YAP/TAZ function as the critical molecular switch to coordinate growth and patterning in gut mesenchyme. Our genetic analyses reveal that Lats1/2 kinases suppress expansion of the primitive mesenchymal progenitors, where YAP activation also prevents induction of the smooth muscle lineage through transcriptional repression of Myocardin. During later development, zone-restricted downregulation of YAP/TAZ provides the positional cue and allows smooth muscle cell differentiation induced by Hedgehog signaling. Taken together, our studies identify the mesenchymal requirement of YAP/TAZ in the gastrointestinal tract and highlight the functional interplays between Hippo and Hedgehog signaling underlying temporal and spatial control of tissue growth and specification in developing gut."xsd:string |
| http://purl.uniprot.org/citations/28943241 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2017.08.019"xsd:string |
| http://purl.uniprot.org/citations/28943241 | http://purl.uniprot.org/core/author | "Li Q."xsd:string |
| http://purl.uniprot.org/citations/28943241 | http://purl.uniprot.org/core/author | "Ma L."xsd:string |
| http://purl.uniprot.org/citations/28943241 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/28943241 | http://purl.uniprot.org/core/author | "Johnson R.L."xsd:string |
| http://purl.uniprot.org/citations/28943241 | http://purl.uniprot.org/core/author | "Park J.S."xsd:string |
| http://purl.uniprot.org/citations/28943241 | http://purl.uniprot.org/core/author | "Mao J."xsd:string |
| http://purl.uniprot.org/citations/28943241 | http://purl.uniprot.org/core/author | "Ip Y.T."xsd:string |
| http://purl.uniprot.org/citations/28943241 | http://purl.uniprot.org/core/author | "Zhu L.J."xsd:string |
| http://purl.uniprot.org/citations/28943241 | http://purl.uniprot.org/core/author | "Ou J."xsd:string |
| http://purl.uniprot.org/citations/28943241 | http://purl.uniprot.org/core/author | "Cotton J.L."xsd:string |
| http://purl.uniprot.org/citations/28943241 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28943241 | http://purl.uniprot.org/core/name | "Dev Cell"xsd:string |
| http://purl.uniprot.org/citations/28943241 | http://purl.uniprot.org/core/pages | "35-47.e4"xsd:string |
| http://purl.uniprot.org/citations/28943241 | http://purl.uniprot.org/core/title | "YAP/TAZ and Hedgehog Coordinate Growth and Patterning in Gastrointestinal Mesenchyme."xsd:string |
| http://purl.uniprot.org/citations/28943241 | http://purl.uniprot.org/core/volume | "43"xsd:string |
| http://purl.uniprot.org/citations/28943241 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28943241 |
| http://purl.uniprot.org/citations/28943241 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28943241 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YVW7-mappedCitation-28943241 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28943241 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YVX7-mappedCitation-28943241 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28943241 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YWC4-mappedCitation-28943241 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28943241 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YWC8-mappedCitation-28943241 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28943241 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YWZ4-mappedCitation-28943241 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28943241 |